insulin analog


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.

insulin analog

A synthetic insulin in which small changes in the amino acid structure of the polypeptide result in changes in the onset, peak effect, or duration of the molecule's physiological effects. Insulin aspart, glargine, and lispro are all insulin analogues.
See also: analogue
References in periodicals archive ?
Long-term intensive treatment of type 1 diabetes with the short-acting insulin analog lispro in variable combination with NPH insulin at mealtime.
A recent comparison (33-35) of premixed insulin analogs vs premixed human insulin formulations suggests similar effectiveness in lowering A1C and FPG levels, but superior effectiveness for premixed analogs in lowering PPG levels (TABLE 1).
The total dose of rapid-acting insulin analog is divided, with 38% delivered at breakfast, 28% at lunch, and 33% at dinner (White RD, et al.
The characteristics of insulin that contribute to variable efficacy, high risk for hypoglycemia, and weight gain can all be reduced by substituting long- and rapid-acting insulin analogs for NPH and regular human insulin, respectively.
According to the company, the two Phase III clinical trials for insulin analog programme are already underway.
A third insulin analog on the market, insulin glulisine (Apidra), approved in 2004, has a pharmacokinetic profile that is similar to insulin aspart and lispro, but Mr.
Within the last decade, newer insulin analogs have become available to replace standard insulin formulations and novel agents and delivery devices have been developed.
Intrapatient insulin absorption can be highly variable and this study evaluates and quantifies the ability of PH20 to produce a more consistent PK profile relative to the PK variability produced by the insulin analog alone.
Various insulin analog formulations allow for improved basal or postprandial coverage, while premixed formulations provide control for both.
Tailored insulin analogs and other long-acting insulins for injection with drug delivery solutions aim at optimized pharmacokinetic profiles in order to avoid hyper- and hypo-glycemic episodes.