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A substance that alters the force of muscular contraction.
[ino- + G. tropos, a turning, change]


(ē″nŏ″trō′pik, ī″nŏ-) [Gr. inos, fiber + -tropic]
1. Influencing the force of muscular contractility.
2. An agent that influences the force of muscular contraction. inotrope (ē′nŏ-trōp″, ī″nŏ) inotropism (ē″trō′pizm)

negatively inotropic

Pert. to an agent that weakens the force of muscular contraction.

positively inotropic

Pert. to an agent that strengthens the force of muscular contraction.


agent influencing muscle tissue contractility


a drug with positive inotropic effects, e.g. dobutamine, digitalis, milrinone.
References in periodicals archive ?
Further studies with a larger sample size and controlling for other confounding factors such as vasoactive and inotropic drug use, mechanical ventilation and systemic vascular resistance may be useful.
The clinical development of this agent has gained the interest of clinicians due to the efficacy and safety of this inotropic drug in the treatment of patients with acute HF
Respiratory failure was defined as requiring ventilatory support and cardiac failure as requiring inotropic drug support.
After admission to the intensive care unit, no inotropic drug was initiated in 4 of these patients except LS; however, other inotropic agents were administered to 7 patients.
Both groups were compared with each other from the aspect of postoperative need for intraaortic balloon counterpulsation (IABP), inotropic drug support, extubation time, length of intensive care unit and hospitalization stays, renal failure, stroke, malignant ventricular arrhythmia, atrial fibrillation, postoperative myocardial infarction and cardiac mortality.
9]/l) 329 [+ or -] 275 Mechanical ventilation 68 (64%) Inotropic drug use 19 (18%) Positive CT angiography patients (%) P Number of CT angiograms 7 (6%) Demographics Age (years) 45 [+ or -] 20 0.
Levosimendan, a new positive inotropic drug, decreases myocardial infarct size via activation of K(ATP) channels.
The endpoints measured were duration of post-operative intubation (an indicator of required respiratory support), increase in thigh circumference after surgery (a measure of edema), total inotropic drug support (which is used to improve heart function) and cardiac output over the first 24 hours after surgery.
ACE inhibitors/ARB antagonists, beta-adrenergic receptor blocking agents, diuretics, and inotropic drugs are the medications available for the treatment of congestive heart failure.
His blood pressure continues to be maintained with three inotropic drugs," S.