Although ventilated and sedated, with temporary pacing wires and box on a back-up mode and a low dose of inotropes
(noradrenalin), the patient is fairly stable.
Dopamine was the most common first-line inotrope
(71%), with dobutamine (23%) and adrenaline (6%).
Rows are organized according to treatments, i.e., baseline ("vehicle"), positive inotrope
("Isoproterenol"), negative inotrope
("Propranolol"), and hERG channel inhibitor ("Cisapride").
Considering the number of patients requiring inotrope
and the duration of inotrope
support in these patients, no significant statistical difference was observed.
Altered sensorium, inotrope
use, CPR, and APACHE II score > 20 had the highest relative risk of mortality.
* Patients who are refractory to fluid management may require inotrope
support, which can be given via the peripheral vascular route.
The saphena wound site infection, mediastinitis, reintubation, bleeding or revision due to sternal dehiscence, temporary neurological deficit, inotrope
and intra-aortic balloon pump requirement (IABP) were the factors extending the emergency care and hospital stay duration and increasing the morbidity.
Mortality was higher in patients with two (35.7%), three (3.3%) or more inotropes
(80%) than in those with one inotrope
(12.1%) or without (2%, p<.0001).
The occurrence of postoperative myocardial infarctions, new onset atrial fibrillation, re-operation for bleeding, vasopressor support in SICU, inotrope
support in SICU, and postoperative requirement for intra-aortic balloon pump are indicators of hemodynamic instability.
have been shown to be associated with a worse outcome, but milrinone, which is both an inotrope
and a vasodilator, may be associated with some improvement in outcome.
An exclusive license for the rights to United States Patent 5,629,298, "Adenosine as a Positive Inotrope
in the Compromised Heart" has been executed with UMMS.
The company says an Investigational Device Exemption (IDE) and Category B were approved by the FDA in connection with the Feasibility Study for Destination Therapy, named INTrEPID (Investigation of Non-Transplant-Eligible Patients who are Inotrope