inositol 1,4,5-trisphosphate

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in·o·si·tol 1,4,5-·tris·phos·phate (IP3),

a second messenger formed from phosphatidylinositol 4,5-bisphosphate; triggers the release of calcium ions from special vesicles of the endoplasmic reticulum; has a role in the activation of neutrophils.
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References in periodicals archive ?
Inositol triphosphate ([IP.sub.3]) is involved in the release of [Ca.sup.2+] from intracellular stores, and increased levels of [IP.sub.3] (25) and inositol phosphate fluxes (26) have been observed in EPEC-infected cells.
PtdIns-4,5P is a key molecule in the "phosphoinositides signaling pathway" of G protein-coupled receptors (GPCRs) associated to phospholipase C, which generate the second messengers diacylglycerol (DAG) and inositol triphosphate (Ins 1,4,5-P).
For instance, myo-inositol is found as free myo-inositol or bound covalently to phospholipids, as the structural basis for a number of secondary messengers, including inositol triphosphates, phosphatidylinositol (PI), and polyphosphoinositides (i.e., PI(4)P, PI(4,5) P2, and PI(3,4,5)P3).