inosine

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Related to Inosine monophosphate: hypoxanthine, guanosine monophosphate, adenosine monophosphate

inosine

 (I) [in´o-sēn]
a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs.
inosine monophosphate (IMP) a nucleotide produced by removal of the amine group from adenosine monophosphate in metabolism of purine nucleotides.

in·o·sine (I, Ino),

(in'ō-sēn),
9-β-d-Ribosylhypoxanthine; a nucleoside formed by the deamination of adenosine.
Synonym(s): hypoxanthinosine

inosine

/in·o·sine/ (I) (in´o-sēn) a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs and as an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage.
inosine monophosphate  (IMP) a nucleotide produced by the deamination of adenosine monophosphate (AMP); it is the precursor of AMP and GMP in purine biosynthesis and an intermediate in purine salvage and in purine degradation.

inosine

(ĭn′ə-sēn′, -sĭn, ī′nə-)
n.
A nucleoside that is involved in purine metabolism, as a precursor and a metabolite of adenosine.

inosine

[in′əsēn, -sīn]
a nucleoside derived from animal tissue, especially intestines, originally used in food processing and flavoring. It has been used in the treatment of cardiac disorders and is now under investigation in studies of cancer and virus chemotherapy. See also inosiplex.

in·o·sine

(I, Ino) (in'ō-sēn)
A nucleoside formed by the deamination of adenosine.

inosine (I)

a NUCLEOSIDE found in some ANTICODONS of TRANSFER RNA. Inosine is ribosylhypoxanthine, the base being hypoxanthine, a derivative of ADENINE. Inosine generally occurs in the first position of the anticodon of certain tRNA molecules where it can base pair with U, C or A of the CODON on mRNA.

inosine

a nucleic acid derivative found naturally in brewer's yeast and organ meats. Not essential in the diet since the body can synthesize it from amino acids and glucose. Metabolically, takes part in formation of adenine, a component of ATP. It has been suggested that inosine supplementation might enhance exercise performance by increasing ATP supply but research studies have found no improvements. See also ergogenic aids; appendix 4.4 .

inosine (īˑ·nō·sēn),

n a nucleoside and precursor to adenosine, important biochemical in energy production. It may be useful as an adjunct treatment for cardiovascular conditions and for Tourette's syndrome. High doses may increase the levels of uric acid in the blood.

inosine

a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs.

inosine monophosphate (IMP)
a nucleotide produced by the deamination of adenosine monophosphate (AMP) in the metabolism of purine nucleotides.
inosine 5-monophosphate
the first fully formed purine nucleotide in the pathway of purine synethesis. Called also IMP or inosinic acid.
References in periodicals archive ?
Induction of inosine monophosphate dehydrogenase activity after long-term treatment with mycophenolate mofetil.
Effects of mycophenolic acid on inosine monophosphate dehydrogenase I and II mRNA expression in white blood cells and various tissues in sheep.
Effects of human T lymphocyte activation on inosine monophosphate dehydrogenase expression.
4] Nonstandard abbreviations: MMF, mycophenolate mofetil; MPA, mycophenolic acid; IMPDH, inosine monophosphate dehydrogenase; CsA, cyclosporin A; PBMC, peripheral blood mononuclear cell; NHL, normal healthy control; FCS, fetal calf serum; NHS, normal human serum; PHA, phytohemagglutinin; PMA, phorbol-12-myristate-13-acetate; IL, interleukin; and Cl, confidence interval.
Structure and mechanism of inosine monophosphate dehydrogenase complex with the immunosuppressant mycophenolic acid.
Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
3) Nonstandard abbreviations: PD, pharmacodynamics; CsA, cyclosporine; AZA, azathioprine; MMF, mycophenolate mofefil; RAPA, rapamycin; CN, calcineurin; PBL, peripheral blood lymphocytes; PP1, PP2A, PP2C, protein phosphatases 1, 2A, and 2C; GVHD, graft vs host disease; 6-MP, 6-mercaptopurine; TPMT, thiopurine methyltransferase; MPA, mycophenolic acid; IMPDH, inosine monophosphate dehydrogenase.
Demonstration of induction of erythrocyte inosine monophosphate dehydrogenase activity in ribavirin-treated patients using high performance liquid chromatography linked method.
VX-497 and VX-148 are potent inhibitors of inosine monophosphate dehydrogenase (IMPDH), a cellular enzyme that is essential for production of guanine nucleotides, one of the building blocks of RNA and DNA.
VX-497 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a cellular enzyme that is essential for production of guanine nucleotides, the building blocks of RNA and DNA.
VX-497 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a human enzyme that is essential for the de novo production of guanosine nucleotides (for example, GTP) -- one of the building blocks of RNA and DNA.
VX-497 is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a human enzyme that is essential for production of nucleotides -- the building blocks of RNA and DNA.