injection site reaction

Also found in: Acronyms.

injection site reaction

An allergic, histaminic, or traumatic response of the skin and subcutaneous tissues to any substance introduced with a needle.

Patient care

The injection site should be carefully monitored for redness, swelling, necrosis, or purulence. The size of any injury should be measured and the patient's level of pain assessed. Management may depend on the nature of the introduced substance. In mild cases, topical application of a cold pack may alleviate symptoms. When a reaction occurs at the site of a vesicant injection (e.g., in patients receiving cancer chemotherapy), close monitoring by a physician or the injection of local antidotes may be required. Reactions that result in infection or necrosis may need to be treated with antibiotics or with surgical débridement.

References in periodicals archive ?
Among its side effects were injection site reactions, increases in alanine aminotransferase (ALT) levels, and steatosis.
Particularly compelling is that even in a small study we were able to observe a statistical difference in injection site reactions," stated Evan M.
The Swiss MS Skin Project was designed to determine the frequency of injection site reactions, including skin necrosis and lipoatrophy, in patients taking AVONEX, Betaferon, Copaxone, or Rebif (ABCRs).
Secondary endpoints at one and two years included inhibition of radiographic progression, safety, injection site reactions and retention.
No serious adverse effects occurred; general adverse effects included fatigue and injection site reactions, including induration and localized pain.
The most frequent adverse reactions in Lupron Depot-PED studies were pain; acne; injection site reactions, including pain, swelling and abscess; rash, including a painful rash with fever, blisters/sores, and facial swelling; vaginitis/vaginal bleeding/vaginal discharge; increased weight; and altered mood.
Common adverse reactions associated with treatment are diarrhea, cholelithiasis, abdominal pain, nausea, and injection site reactions, according to the label.
The most common adverse events involved injection site reactions, which affected 34% of subjects.
The most commonly observed adverse reactions during FIRMAGON therapy included injection site reactions (e.
Local injection site reactions occurred in almost all of the patients who used the drug.
In addition to the possibility of monthly dosing convenience, the data suggests that patients treated with AZ01 will experience a reduction in the days per month with flu-like symptoms and minimal to no injection site reactions.
In clinical trials comparing the safety and tolerability of Sumavel DosePro to sumatriptan injection, most injection site reactions resolved spontaneously.