Injection site reactions
were the most common adverse event, occurring in 78% of the mipomersen group and 31% of the placebo group.
The Swiss MS Skin Project was designed to determine the frequency of injection site reactions
, including skin necrosis and lipoatrophy, in patients taking AVONEX, Betaferon, Copaxone, or Rebif (ABCRs).
The incidence of injection site reactions
in the subcutaneous group was 2.
Although injection site reactions
are relatively common, serious adverse effects have not been reported.
Besides, there were more injection site reactions
with the use of anakinra and also the rate of serious infections with anakinra was touching statistical significance when compared to placebo.
The most common side effects of Cimzia are headache, upper respiratory infections, abdominal pain, injection site reactions
Etanercept is administered by subcutaneous injections; the injection site reactions
are typically limited to local hyperaemia and oedema and there is no evidence of local cell death or tissue necrosis (5).
The new version cut them almost in half and also slashed injection site reactions
VIVITROL injections may be followed by pain, tenderness, induration, swelling, erythema, bruising or pruritus; however, in some cases injection site reactions
may be very severe.
In the ODYSSEY CHOICE I study in which all patients received an injection of Praluent or placebo every two weeks to maintain the blind, local injection site reactions
were reported more frequently in patients treated with Praluent 300 mg every four weeks as compared to those receiving Praluent 75 mg every two weeks or placebo (16.
Most side effects were local injection site reactions
, were mild to moderate and were resolved within a short period after drug application.
Headache and injection site reactions
were the only adverse events more common with dupilumab than with placebo in the phase lib trial, with the incidence of injection site reactions
showing a possible dose-response relationship.