Most of the studies suggest the positive role of iron on HCV translation, the mechanisms of which involve increased expression levels of factors associated with HCV internal ribosome entry site-dependent translation, such as eukaryotic initiation factor 3 and La protein.
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3.
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (elF4E) axis.
Fold Gene Description change elF2 signaling E1F1AX Eukaryotic translation initiation factor 1A, -1.
Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas.
An important level of control of eukaryotic gene expression occurs during initiation of cap-mediated messenger RNA translation by the eukaryotic initiation factor 4F (eIF-4F) trimolecular complex (composed of eIF-4E, eIF-4G, and eIF-4A), in which eIF-4E is rate limiting and oncogenic.
Targeting the eukaryotic translation initiation factor 4E for cancer therapy.
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Modulation of ribosomal recruitment to 5'-terminal start codons by translation initiation factors IF2 and IF3.
Selective stimulation of translation of leaderless mRNA by initiation factor 2: evolutionary implications for translation.
Evolutionary relationship between translation initiation factor elF2gamma and selenocysteine-specific elongation factor SELB: change of function in translation factors.
Phosphorylation of initiation factor
2[Alpha] by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast.