inhibitory postsynaptic potential

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in·hib·i·tor·y post·syn·ap·tic po·ten·tial (IPSP),

the change in potential produced in the membrane of the next neuron when an impulse that has an inhibitory influence arrives at the synapse; it is a local change in the direction of hyperpolarization; the frequency of discharge of a given neuron is determined by the extent to which impulses that lead to excitatory postsynaptic potentials predominate over those that cause inhibitory postsynaptic potentials.
Farlex Partner Medical Dictionary © Farlex 2012

in·hib·i·tor·y post·syn·ap·tic po·ten·tial

(in-hib'i-tōr-ē pōst'si-nap'tik pŏ-ten'shăl)
The change in potential produced in the membrane of the next neuron when an impulse that has an inhibitory influence arrives at the synapse; it is a local change in the direction of hyperpolarization.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
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References in periodicals archive ?
Neuroligins are transmembrane cell adhesion proteins that are involved in the regulation of excitatory and inhibitory synapses [32, 33].
The interaction of neurexin and neuroligin can induce both presynaptic and postsynaptic terminals differentiation and meditate synaptogenesis of both excitatory and inhibitory synapse and maintain their balance in vitro [3, 4].
Age-dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens-lacunosum moleculare interneurons.
The quick response of the [GABA.sub.A] receptor is due to its high affinity for the inhibitory synapses and it is believed that they are saturated even by the release of a single vesicle of neurotransmitter [26].
Shin et al., "Effects of A2 type botulinum toxin on spontaneous miniature and evoked transmitter release from the rat spinal excitatory and inhibitory synapses," Toxicon, vol.
From the neurophylogenetic perspectives, the ultrastructural characteristics of the central nervous tissue of the Onychophora show important evolutionary acquirements, such as the presence of both excitatory and inhibitory synapses, indicating functional synaptic transmission, and the appearance of mature glial cells.
Topics include AMPA receptor trafficking, long-term plasticity at inhibitory synapses, proteomics of the PSD, phosphorylation of site-specific antibodies, protein palmitoylation by the DHHC protein family, antibody labeling and biotinylation approaches to study neurotransmitter receptors, visualization of AMPAR trafficking and surface expression, neurotransmitter dynamics, receptors dynamics and functional tagging, RNAi and applications in neurobiology, transfecting and transducing neurons, expression of recombinant proteins in rat brains using Sindbus virus, Lentivirus-based genetic manipulation, AMPA receptor phosphorylation in synaptic plasticity, and genomic and post-genomic tools for studying synapse biology.
The increase in the level of cell polarization can be passive, due to reduced excitatory influence, and active, due to the activation of inhibitory synapses and the development of inhibitory postsynaptic potential (IPSP), according to contemporary conceptions.
On the other side, phenytoin may also block the release in inhibitory synapses, in such a manner that the final result will be the sum of its effects on these systems.
Presynaptic protein complexin I is a marker of inhibitory synapses, and complexin II is a marker of excitatory synapses.
"We have both excitatory and inhibitory synapses," Dr.
This is represented in the model by the distribution of excitatory and inhibitory synapses on the cell bodies in the third layer.