enzyme inhibitor

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enzyme inhibitor

a molecule that prevents an enzyme from catalysing a reaction. Such inhibitors can compete with the normal substrate (see COMPETITIVE INHIBITION or can block the active site, preventing entry of the substrate (see NONCOMPETITIVE INHIBITION). Inhibition may be reversible or irreversible. Enzyme inhibitors often form part of a FEEDBACK MECHANISM to regulate a biochemical pathway.
References in periodicals archive ?
A]), and the inhibition constant of the other ligand.
The inhibition constant (Ki value) and mechanism were elucidated for compounds which shown strong inhibitory potential.
Interactions of inhibitors with the free Canavalia ensiformis or Bacillus pasteurii urease represented by K1 and the Canavalia ensiformis or Bacillus pasteurii urease-urea complexes represented by AYK1 inhibition constant.
Kinetic study of angustidine (2) on BChE suggested a mixed inhibition mode with an inhibition constant (Ki) of 6.
A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition.
Relationship between the inhibition constant (K) and the concentration of inhibitor which causes 50 per cent inhibition (ISO) of an enzymatic reaction.
This had been held at -80 [degrees] and still gave a second order AChE inhibition constant of 3.
The inhibition constant (Ki) for the inhibitors were calculated at 2 or 3 fixed concentrations of inhibitors.
Meanwhile, the other inhibition parameters, including inhibition types and inhibition constant ([K.
The inhibition constant (Ki), the inhibitor concentration at which the reaction is half of the maximal rate, was obtained by a secondary plot using the slope of the primary Lineweaver-Burk Plot and fitted by V0 GraphPad Prism 4.
5-10 [micro]g/m1) competitively inhibited human and rat liver microsomal CYP1A2 activity with inhibition constant ([K.
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (1C50) of an enzymatic reaction.