inflammatory bowel disease

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inflammatory bowel disease

 
any of various inflammatory diseases of the bowel whose etiology is unknown, including crohn's disease and ulcerative colitis.

inflammatory bowel disease (IBD),

general term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, of unknown cause, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

inflammatory bowel disease

n. Abbr. IBD
Any of several chronic disorders of the gastrointestinal tract, especially Crohn's disease and ulcerative colitis, characterized by inflammation and ulceration of the intestine and resulting in abdominal cramping and diarrhea.

inflammatory bowel disease

inflammatory bowel disease

A general term for the symptoms associated with specific types of inflammation of the large intestine, including Crohn's disease–CD, ulcerative colitis–UC as well as idiopathic inflammatory bowel disease, a diagnosis of exclusion that clinically and pathologically mimics and/or overlaps CD and UC Heredity First-degree relatives of Pts with CD and UC have an 8- to 10-fold ↑ risk of developing the same form of colitis DiffDx Ischemia, radiation, uremia, cytotoxic drugs, heavy metal intoxication; IBD Pts often have ≥ 2 of following: Visible abdominal distension, relief of pain upon defecation, looser and more frequent bowel movements when the pain occurs; ♂:♀ ratio, 2:1; more common in Jews; IBD is associated with mucocutaneous disease–pyoderma gangrenosa, erythema nodosum, oral ulcers, annular erythema, vascular thromboses, epidermolysis bullosa, ocular disease–uveitis, iridocyclitis, hepatopathy–CAH, cirrhosis, sclerosing cholangitis, arthropathy–ankylosing spondylitis. Cf Irritable bowel syndrome Treatment Corticosteroids—or corticotropin–favored by some clinicians, aminosalicylates–sulfasalazine and 5-aminosalicylic acid, immunomodulatory agents–azathioprine, mercaptopurine, cyclosporine, MTX, metronidazole, antibiotics and nutritional support–both more effective in Crohn's disease, resulting in ↓ Sx, ↓ inflammatory sequelae, improved nutritional status.
Inflammatory bowel disease  
Clinical  Ulcerative colitis Crohn's disease
Rectal bleeding  Common  Rare
Abdominal mass  Rare  10-15%
Abdominal pain  Left-sided  Right-sided
Abnormal endoscopy  95%  < 50%
Perforation  12%  4%
Colon carcinoma  5-10%  Rare
Response to steroids  75%  25%
Surgical outcome Excellent  Fair
Rectal involvement  > 95%  !0%
Radiology
Ileal involvement  Rare  Usual
Cross-hatched ulcers  Rare  Occasional
Thumbprinting  Absent  Common
Fissuring  Absent  Common
Skip areas  Absent  Common
Strictures  Absent  Common
Pathology
Distribution  Diffuse  Focal
   Superficial  Transmural
Mucosal atrophy Regeneration  Marked Minimal
Hyperemia  Often marked  Minimal
Crypt abscess  Common  Rare
Cytoplasmic mucin  Decreased  Intact
Lymphoid aggregates  Rare  Common
Lymph nodes  Reactive hyperplasia  -----
Edema  Minimal Marked
Granulomas  Absent  60%  

in·flam·ma·to·ry bow·el dis·ease

(IBD) (in-flam'ă-tōr-ē bow'ĕl di-zēz')
General term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, autoimmune, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

Inflammatory bowel disease (IBD)

Ulcerative colitis or Crohn's colitis; chronic conditions characterized by periods of diarrhea, bloating, abdominal cramps, and pain, sometimes accompanied by weight loss and malnutrition because of the inability to absorb nutrients.

inflammatory

pertaining to or emanating from inflammation.

inflammatory bowel disease
an idiopathic disease of cats, principally, and dogs characterized by cyclic bouts of vomiting and or diarrhea which may continue over periods of years; see also lymphocytic-plasmacytic enteritis.
inflammatory edema
a disease of the subcutis caused usually by Clostridium spp.
inflammatory response
References in periodicals archive ?
4 A growing tendency in the incidence and prevalence of inflammatory bowel disease (IBD) in Asia has been documented for the past two decades.
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M2 EQUITYBITES-June 19, 2014-Pluristem wins patent in Russia for treating inflammatory bowel disease using placenta-derived cells
Globally, the number of children and adolescents afflicted by inflammatory bowel disease has been increasing in recent years.
Gut stem cells appear to be able to repair tissue damage due to inflammatory bowel disease in tests on mice, according to a team of researchers from the Cambridge Stem Cell Institute at the University of Cambridge, and BRIC, the University of Copenhagen, Denmark.
These molecules prevent misplaced immune attacks in inflammatory bowel diseases like colitis, a new study finds.
This report provides information on the therapeutic development for Inflammatory Bowel Disease, complete with latest updates, and special features on late-stage and discontinued projects.

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