inflammatory bowel disease

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inflammatory bowel disease

 
any of various inflammatory diseases of the bowel whose etiology is unknown, including crohn's disease and ulcerative colitis.

inflammatory bowel disease (IBD),

general term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, of unknown cause, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

inflammatory bowel disease

n. Abbr. IBD
Any of several chronic disorders of the gastrointestinal tract, especially Crohn's disease and ulcerative colitis, characterized by inflammation and ulceration of the intestine and resulting in abdominal cramping and diarrhea.

inflammatory bowel disease

inflammatory bowel disease

A general term for the symptoms associated with specific types of inflammation of the large intestine, including Crohn's disease–CD, ulcerative colitis–UC as well as idiopathic inflammatory bowel disease, a diagnosis of exclusion that clinically and pathologically mimics and/or overlaps CD and UC Heredity First-degree relatives of Pts with CD and UC have an 8- to 10-fold ↑ risk of developing the same form of colitis DiffDx Ischemia, radiation, uremia, cytotoxic drugs, heavy metal intoxication; IBD Pts often have ≥ 2 of following: Visible abdominal distension, relief of pain upon defecation, looser and more frequent bowel movements when the pain occurs; ♂:♀ ratio, 2:1; more common in Jews; IBD is associated with mucocutaneous disease–pyoderma gangrenosa, erythema nodosum, oral ulcers, annular erythema, vascular thromboses, epidermolysis bullosa, ocular disease–uveitis, iridocyclitis, hepatopathy–CAH, cirrhosis, sclerosing cholangitis, arthropathy–ankylosing spondylitis. Cf Irritable bowel syndrome Treatment Corticosteroids—or corticotropin–favored by some clinicians, aminosalicylates–sulfasalazine and 5-aminosalicylic acid, immunomodulatory agents–azathioprine, mercaptopurine, cyclosporine, MTX, metronidazole, antibiotics and nutritional support–both more effective in Crohn's disease, resulting in ↓ Sx, ↓ inflammatory sequelae, improved nutritional status.
Inflammatory bowel disease  
Clinical  Ulcerative colitis Crohn's disease
Rectal bleeding  Common  Rare
Abdominal mass  Rare  10-15%
Abdominal pain  Left-sided  Right-sided
Abnormal endoscopy  95%  < 50%
Perforation  12%  4%
Colon carcinoma  5-10%  Rare
Response to steroids  75%  25%
Surgical outcome Excellent  Fair
Rectal involvement  > 95%  !0%
Radiology
Ileal involvement  Rare  Usual
Cross-hatched ulcers  Rare  Occasional
Thumbprinting  Absent  Common
Fissuring  Absent  Common
Skip areas  Absent  Common
Strictures  Absent  Common
Pathology
Distribution  Diffuse  Focal
   Superficial  Transmural
Mucosal atrophy Regeneration  Marked Minimal
Hyperemia  Often marked  Minimal
Crypt abscess  Common  Rare
Cytoplasmic mucin  Decreased  Intact
Lymphoid aggregates  Rare  Common
Lymph nodes  Reactive hyperplasia  -----
Edema  Minimal Marked
Granulomas  Absent  60%  

in·flam·ma·to·ry bow·el dis·ease

(IBD) (in-flam'ă-tōr-ē bow'ĕl di-zēz')
General term for Crohn disease and ulcerative colitis, chronic disorders of the small and large intestine, autoimmune, with conspicuous inflammatory features and distinctive but overlapping signs and symptoms.

Inflammatory bowel disease (IBD)

Ulcerative colitis or Crohn's colitis; chronic conditions characterized by periods of diarrhea, bloating, abdominal cramps, and pain, sometimes accompanied by weight loss and malnutrition because of the inability to absorb nutrients.

inflammatory

pertaining to or emanating from inflammation.

inflammatory bowel disease
an idiopathic disease of cats, principally, and dogs characterized by cyclic bouts of vomiting and or diarrhea which may continue over periods of years; see also lymphocytic-plasmacytic enteritis.
inflammatory edema
a disease of the subcutis caused usually by Clostridium spp.
inflammatory response
References in periodicals archive ?
A snapshot of the global therapeutic scenario for Inflammatory Bowel Disease.
44) investigated venous thromboembolism risk between periods of inflammatory bowel disease and found that cases in active period were more risky in pre-hospitalization period compared to the patients who were hospitalized.
In conclusion: the presence of the fat halo sign may in the absence of clinical and radiological features of inflammatory bowel disease represent a normal finding that may also be related to obesity.
The investigators found 36 cases of pediatric inflammatory bowel disease with full prescribing records.
Taking into account this case report and the incidence of thromboembolic events in human patients with IBD, further studies are required to investigate the rate of thromboembolism or hypercoagulability in dogs with inflammatory bowel disease.
Untreated depression increases the likelihood that patients with inflammatory bowel disease will not adhere to medication regimens, leading to treatment failure, other studies have shown.
Currently our recommendations are that inflammatory bowel disease patients should be counseled to avoid conventional NSAIDs if at all possible, and should proceed cautiously with the use of selective COX [cyclooxygenase]-2 inhibitors based on the data that we have to date," said Dr.
Researchers announced that there was no evidence that MMR or single measles vaccines are linked with autism or inflammatory bowel disease.
The study, to be published in the medical journal Molecular Pathology in April, found that the virus may act as a trigger for both conditions, including the painful inflammatory bowel disease colitis.
Controversy has since raged over whether there are any proven links between the vaccine and autism and inflammatory bowel disease.
Crohn's disease is a chronic inflammatory bowel disease characterized by discontinuous involvement of the entire alimentary tract, from the mouth to the anus.

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