NOS2

(redirected from Inducible NOS)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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There are three types of NOS: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS).
There are three distinct isoforms of NOS in mammalian cells including neuronal NOS (nNOS, Type I), inducible NOS (iNOS, Type II) and endothelial NOS (eNOS or Type III) (4).
IHC and scoring were conducted as described.[9] Primary antibodies of inducible NOS (iNOS) (mouse, Abcam, ab129372), neuronal NOS (nNOS) (rabbit, Abcam, ab3511), Cav1.2 (mouse, Abcam, ab84814), Cav1.3 (mouse, Abcam, ab85491), IP[sub]3R1 (rabbit, Abcam, ab125076), IP[sub]3R2 (rabbit, Millipore, ab9074), IP[sub]3R3 (rabbit, Millipore, ab9076), and RyR2 (rabbit, Chemicon, ab9080) were diluted at 1:100.
Three isoforms of NOS have been identified: neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS).
NO is produced from L-arginine by NOS [36], an enzyme with different isoenzymes (neuronal NOS or nNOS, inducible NOS or iNOS, endothelial NOS or eNOS, and mitochondrial NOS or mtNOS).
Wu and Meininger (2002) demonstrated that inadequate intake of dietary arginine impairs NO synthesis by both constitutive and inducible NOS in animals, indicating a role of adequate arginine nutrition in immune function.
The isoforms of NOS are subdivided into three basic categories: endothelial NOS, neuronal NOS and inducible NOS (iNOS), all of which are encoded by separate genes and, therefore, differently regulated.
Neuronal and inducible NOS are more commonly found in their soluble form than the membrane-bound one.
NSO and volatile component of NS seed, TQ were found to improve antioxidant capacity induced by several agents in different animal tissues by suppressing oxidative/nitrosative stress, N[O.sup.*] overproduction and inducible NOS expression.
Thus, the dynamic reduction activities ofNO and eNOS occurred against a background of increasing the activity of inducible NOS and concentration of [ONO-.sub.2] (Table 1).
Oxidative stress is known to upregulate the synthesis of neuronal and inducible NOS, leading to overproduction of NO, which acts as a neurodestructive agent by the production of peroxynitrites.
NOSs are classified to three forms, that is, endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS).