NOS2

(redirected from Inducible NO synthase)

NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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Zhou et al., "The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway," Free Radical Biology and Medicine, vol.
Stuehr, "Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability," The Journal of Biological Chemistry, vol.
Geromin et al., "Regulation of ICAM1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase,' Journal of Leukocyte Biology, vol.
These so-called classically activated macrophages, or M1 macrophages, produce large amounts of proinflammatory cytokines, reactive oxygen intermediates, and such reactive nitrogen intermediates as nitric oxide (NO), which is generated by inducible NO synthase (iNOS) encoded by the Nos2 gene [4, 5].
This cardioprotective effect was completely abolished with the use of either a NO inhibitor or an inducible NO synthase blocker, affirming resveratrol's beneficial action.
Muscular structure, enzyme activity, constitutive and inducible nitric oxide (NO) synthases (endothelial NO oxide synthase [eNOS], neuronal NO synthase [nNOS] and inducible NO synthase [iNOS]), nitrites, nitrates, nitrotyrosine, and the presence of macrophages were analyzed.
A key proinflammatory mediator produced in the intestinal mucosa is the free radical nitric oxide (NO), synthesized by inducible NO synthase (iNOS).[33,34] Inflammatory stimuli, such as endotoxin and the cytokines IL-1 and TNF-[Alpha], can induce iNOS in a variety of inflammatory cells, including macrophages and neutrophils, and in vascular endothelium and smooth muscle.[35-36] Studies in patients with IBD have shown a marked increase in NO synthesis and iNOS activity in the inflammatory mucosa.[37-38]
Inducible NO synthase (iNOS)[3] activity stimulated at the site of infection is primarily responsible for the sustained release of NO (2).
To assess nitrosative stress, adjacent brain sections were stained for nitrotyrosine, inducible NO synthase (iNOS), neuronal NO synthase (nNOS), and endothelial NO synthase (eNOS), respectively.
NO is synthesized from L-arginine (Arg) by constitutive and inducible NO synthase (NOS) isoforms.