In this reprogramming technique, somatic cells are converted into induced pluripotent stem cells
They used four regulator genes to create the cells, called induced pluripotent stem cells
Human induced pluripotent stem cells
(hiPSCs) are generated from adult cells and can be programmed to change into any cell type in the body.
SEATTLE, Wash., November 30, 2016--The Allen Institute for Cell Science has released the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells
that target key cellular structures with unprecedented clarity.
Induced pluripotent stem cells
give researchers an alternative to embryonic stem cells that could allow the creation of therapeutic matching the genetic makeup of each patient, greatly reducing the chances of cell rejection after they were infused or transplanted.
The cells, called "induced pluripotent stem cells
" (iPS), are nearly identical to the naturally occurring pluripotent stems cells, such as embryonic stem cells, which are highly pluripotent, in short supply and their access restricted in the U.S.
Bjorn Knollman of Vanderbilt University School of Medicine noted the "ugly truth" that everyone recognized in 2013: cardiomyocytes derived from induced pluripotent stem cells
were nothing like normal adult cardiomyocytes in shape, size and function.
The researchers solved this problem by reprogramming skin cells into so called induced pluripotent stem cells
which they differentiated into hepatocyte like cells.
The findings highlight a scalable monolayer system to differentiate human pluripotent stem cells into skeletal muscle cells and demonstrate disease-specific phenotypes in muscle derived from both human embryonic and induced pluripotent stem cells
affected with FSHD.
LA JOLLA, Calif., December 12, 2016 -- Researchers here who looked at the effect of aging on induced pluripotent stem cells
(iPSCs) found that genetic mutations increased with the age of the donor who provided the source cells.
The NSCF/MJFF-funded study will further explore implantation of dopamine neurons made from induced pluripotent stem cells
(iPSCs) in the brains of non-human primates.
The findings highlight a scalable monolayer system to differentiate human pluripotent stem cells into skeletal muscle cells and demonstrate diseasespecific phenotypes in muscle derived from both human embryonic and induced pluripotent stem cells
affected with FSHD.