indole

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Related to Indole ring: tryptophan, pyrrole ring

indole

 [in´dōl]
a compound obtained from coal tar and indigo and produced by decomposition of tryptophan in the intestine, where it contributes to the peculiar odor of feces. It is excreted in the urine in the form of indican.

in·dole

(in'dōl), Avoid the misspelling indol.
1. basis of many biologically active substances (for example, serotonin, tryptophan); formed in degradation of tryptophan. Synonym(s): ketole
2. Any of many alkaloids containing the indole (1) structure.

indole

(ĭn′dōl′)
n.
1. A white crystalline compound, C8H7N, obtained from coal tar or various plants and produced by the bacterial decomposition of tryptophan in the intestine. It is used in perfumes and as a reagent.
2. Any of various derivatives of this compound.

indole

Chemistry
A heterocyclic compound that is the parent molecule for serotonin tryptophan and other alkaloids; indoles are present in broccoli, cabbage and other cruciferous vegetables, and may have anticarcinogenic activity.

in·dole

(in'dōl)
1. 2,3-benzopyrrole; basis of many biologically active substances (e.g., serotonin, tryptophan); formed in degradation of tryptophan.
Synonym(s): ketole.
2. Any of many alkaloids containing the indole (1) structure.

indole

2,3-benzopyrrole, an unpleasant-smelling product of protein breakdown that contributes to the odour of the faeces. In high dilution, indole has a pleasant smell and has been used in the perfumery industry. See also SKATOLE.
References in periodicals archive ?
The presence of methyl group at the fifth position of the indole ring plays an important role as a better electron donor which enhances reducing power activity of the compounds.
140[degrees]C; IR (KBr): 3422, 3152, 2982, 1708, 1675, 1593, 1530, 1420, 1091[cm.sup.-1]; [sup.1]H NMR ([delta] ppm DMSO-[d.sub.6]): 2.01 (s, 2H, N[H.sub.2] of triazole ring), 2.78 (dd, 1H, CH), 3.88 (t, 1H, CH), 6.80 (s, 1H, CH), 7.0 (s, 1H, N-H of triazole ring), 7.44 (s, 1H, CH), 6.87-7.53 (m, 4H, aromatic), 8.2 (s, 1H, NH of indole ring), 11.0 (s, 1H, OH), 13.4 (s, 1H, NH).
170[degrees]C; IR (KBr): 3427, 3150, 2980, 1701, 1672, 1592, 1533, 1424, 1094 [cm.sup.-1]; [sup.1]H NMR ([delta] ppm DMSO-[d.sub.6]): 0.96 (t, 3H, C[H.sub.3]), 1.06 (d, 3H, C[H.sub.3]), 1.29 (m, 2H, C[H.sub.2]), 2.03 (s, 2H, N[H.sub.2] of triazole ring), 2.21 (m, 2H, C[H.sub.2]), 3.48 (d, 1H, CH), 7.0 (s, 1H, N-H of triazole ring), 6.88-7.52 (m, 4H, aromatic), 8.1 (s, 1H, NH of indole ring), 11.1 (s, 1H, OH).
195[degrees]C; IR (KBr): 3433, 3155, 2988, 1709, 1678, 1595, 1533, 1427, 1094 [cm.sup.-1]; [sup.1]H NMR ([delta] ppm DMSO-[d.sub.6]): 1.01 (d, 3H, C[H.sub.3]), 1.03 (d, 3H, C[H.sub.3]), 2.1 (s, 2H, N[H.sub.2] of triazole ring), 2.39 (m, 1H, CH), 3.49 (d, 1H, CH), 7.1 (s, 1H, N-H of triazole ring), 6.87-7.54 (m, 4H, aromatic), 8.2 (s, 1H, NH of indole ring), 11.2 (s, 1H, OH).
[sup.1]H NMR in (DMSO-[d.sub.6]), [delta]: 2.25 (s, 3H, -C[H.sub.3]); 4.91-4.84 (m, 2H, -O-C[H.sub.2]-C[F.sub.3]); 5.60 (s, 2H, -N-CH2-pyridine ring); 7.24-7.19 (d, 1H, vinylic proton); 7.93 (s, 1H, indole ring protons); 7.72 (d, 1H, vinylic proton); 7.35-8.30 (m, 9H, Ar-H); 7.49 (d, 1H, pyridine-H); 8.27 (d, 1H, pyridine-H).
[sup.1]H NMR in (DMSO-[d.sub.6]), [delta]: 2.27 (s, 3H,- C[H.sub.3]); 4.94-4.87 (m, 2H, -O-C[H.sub.2]-C[F.sub.3]); 5.64 (s, 2H, -N-C[H.sub.2]-pyridine ring); 7.29-7.21 (d, 1H, vinylic proton); 7.94 (s, 1H, indole ring protons); 7.77 (d, 1H, vinylic proton); 7.38-8.33 (m, 8H, Ar-H); 7.53 (d, 1H, pyridine-H); 8.31 (d, 1H, pyridine-H).
[sup.1]H NMR in (DMSO-[d.sub.6]), [delta]: 2.20 (s, 3H,- C[H.sub.3]); 4.88-4.80 (m, 2H, -O-C[H.sub.2]-C[F.sub.3]); 5.56 (s, 2H, -N-C[H.sub.2]-pyridine ring); 7.20-7.30 (d, 1H, vinylic proton); 7.86 (s, 1H, indole ring protons); 7.67 (d, 1H, vinylic proton); 73-8.23 (m, 8H, Ar-H); 7.44 (d,1H, pyridine-H); 8.21 (d, 1H, pyridine-H).
The increased scavenging activity is due to the presence of halogen, methyl, and methoxy substitution at the five positions and a phenyl ring at the third position of indole ring. The hydrogen of indole NH/imidazolopyridine NH could be donated to the DPPH to form DPPH free radical; by the presence of phenyl ring at third position of indole, the DPPH free radical will be stabilized by the resonance.
The presence of methyl and methoxy groups at five positions of indole ring has enhanced the ferric reducing power activity of the compounds.
Very promising scavenging, antioxidant, and antimicrobial activities are observed with compounds containing halogens, methyl, and methoxy groups at five positions and a phenyl ring at the third position of indole ring. Excellent ferric reducing activity is observed with compounds containing C[H.sub.3] and OC[H.sub.3] at five positions of indole.
Considering the findings to date, it is reasonable to postulate the hemodialysis-induced cascade interaction model in fatty acid-uremic toxin-drug systems, in which a transient increase in the concentrations of long-chain fatty acids could produce a cascade displacement of both site I- and II-bound drugs by their competitive inhibitors, namely, CMPF and uremic toxins that contain an indole ring (see Fig.
Six aromatic protons provided a clue concerning the constitution of two indole rings with the substitutions.