A fatal disease of early childhood onset with familial tendencies first described in the middle classes of rural India, which occurs elsewhere in the tropics and subtropics Lab Increased immunoglobulins, increased serum and hepatic copper Pathogenesis Idiopathic, cooking in copper cookware
Although hyalin bodies were first described in alcoholic liver disease, they are also present in nonalcoholic steatohepatitis, Indian childhood cirrhosis, and Wilson's disease, and in the livers of patients receiving amiodarone therapy.
However, several studies have demonstrated with serial liver biopsies that fibrosis may decrease with time in some cirrhotic livers. This partial regression has been documented in diseases in which progression can be arrested by therapy, as in alcoholism, hemochromatosis, Wilson disease, Indian childhood cirrhosis, autoimmune hepatitis, and chronic hepatitis C virus.
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.