A fatal disease of early childhood onset with familial tendencies first described in the middle classes of rural India, which occurs elsewhere in the tropics and subtropics Lab Increased immunoglobulins, increased serum and hepatic copper Pathogenesis Idiopathic, cooking in copper cookware
Although hyalin bodies were first described in alcoholic liver disease, they are also present in nonalcoholic steatohepatitis, Indian childhood cirrhosis, and Wilson's disease, and in the livers of patients receiving amiodarone therapy.
1] This partial regression has been documented in diseases in which progression can be arrested by therapy, as in alcoholism, hemochromatosis, Wilson disease, Indian childhood cirrhosis, autoimmune hepatitis, and chronic hepatitis C virus.
17] At least partial regression of human cirrhosis has been documented in treated patients having biliary obstruction, hemochromatosis,[19-22] Wilson disease,[23,24] intestinal bypass-related cirrhosis, Indian childhood cirrhosis, autoimmune hepatitis, primary biliary cirrhosis, chronic viral hepatitis,[29-32] and alcoholic liver disease.
Reversal of Indian childhood cirrhosis by D-penicillamine therapy.