incretin

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Related to Incretins: glucagon

in·cre·tin

(in-krē'tin),
Generic term for all insulinotropic substances originating in the gastrointestinal tract that are released into the circulation by meals containing glucose. One is glucose-dependent insulinotropic polypeptide, which is released into the circulation from crypt cells in the proximal duodenum and jejunum after meals containing glucose or long-chain fatty acids. Another is proglucagon-derived polypeptide, cleavage product of glucagon, which is further processed into glucagonlike peptide-1 and then to glucagonlike insulinotropic peptide.
Farlex Partner Medical Dictionary © Farlex 2012

incretin

(ĭn-krēt′n)
n.
Any of several gastrointestinal hormones that bring about the release of insulin from the pancreas after carbohydrate ingestion and are essential in maintaining normal levels of glucose in the blood.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

in·cre·tin

(in-krē'tin)
Generic term for all insulinotropic substances originating in the gastrointestinal tract that are released into the circulation by meals containing glucose. One is the glucose-dependent insulinotropic polypeptide, which is released into the circulation from crypt cells in the proximal duodenum and jejunum after meals containing glucose or long-chain fatty acids. Another is proglucagon-derived polypeptide, a cleavage product of glucagon, which is further processed into glucagonlike peptide-1 and then to glucagonlike insulinotropic peptide.
Compare: bioregulator
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

in·cre·tin

(in-krē'tin)
Generic term for all insulinotropic substances originating in the gastrointestinal tract.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
However, in Type 2 diabetes, an incretin called glucagon-like peptide 1 (GLP-1) is in short supply or is affected by a protein that makes it inactive.
Incretins are hormones released by intestinal cells in response to ingested nutrients, especially glucose.
"Certainly with gastric bypass, we talk about foregut and hindgut theory in terms of incretin effect,"
They both incretins reduce intestinal motility, extend the time of gastric emptying, and suppress gastric acid secretion, particularly in the gastrointestinal tract (3, 4).
(i) enteric hormonal modulation and the incretin theory,
Drucker, "Biology of incretins: GLP-1 and GIP," Gastroenterology, vol.
Sanlioglu, "Incretins: their physiology and application in the treatment of diabetes mellitus," Diabetes/Metabolism Research and Reviews, vol.
Incretins-based therapy includes incretin mimetics, i.e., GLP-1 analogs such as exenatide, lixisenatide, liraglutide, and incretin enhancers, i.e., DPP-4 inhibitors such as sitagliptin, vildagliptin, and teneligliptin.
Incretins are hormones secreted by the small intestine in response to glucose from a meal.
But the risk of cancer diminished over time, suggesting that there was no causal relationship between incretins and pancreatic cancer.
demonstrated that DPP-4i reduced the expressions of Lox-1 and CD36 in macrophages [15], suggesting DPP-4i directly suppressed the macrophage foam cell formation, independent of incretins. Thus, this is the first study to demonstrate that combination therapy can remarkably suppress expression of both Lox-1 and CD36 associated with the reduction of foam cell formation.
That's where the incretins come into play, he said.