Iktos is developing a proprietary and innovative solution based on deep learning generative models, which enables the use of existing data to design molecules that are optimized in silico
to meet the success criteria of a small molecule discovery project.
Food and Drug Administration (FDA) has been investigating the in silico
approach since 2011 and is now strongly encouraging the adoption of this technology by medical device companies.
Schneider closed his talk leading over to in silico
methods including frameworks for high quality science, planning experiments and power analysis over databases, visualization tools and data analysis procedures, prediction models, and quantitative structure-activity relationships.
The current release of ICE features in vivo and in vitro data sets covering regulatory test end points such as acute oral and dermal toxicity, skin irritation and sensitization, eye corrosion, and endocrine disruption as well as in silico
predictions of test end points and chemical properties (Table 1).
Banerjee, "Structural stability, transitions, and interactions within SoxYZCD-thiosulphate from Sulfurimonas denitrificans: an in silico
molecular outlook for maintaining environmental sulphur cycle," Journal of Biophysics, vol.
The reason for this drive towards in silico
medicine is largely down to the challenges of treating an ageing population.
In the case presented here (indeed emerging and MDR), the NGS-based in silico
spoligotyping would confuse the MDR/extensively drug resistant SIT266 with "less dangerous" SIT264.
Contributed by pharmaceutical and other scientists from Europe, the US, and Argentina, the 18 chapters in this volume outline the theory, methods, challenges, and applications of in silico
methods for drug discovery and design, discussing the theoretical framework and algorithms of computer-aided drug discovery and design, the range of validity, the strengths and limitations of each methodology, and applications to real-world drug discovery problems.
but the in silico
world is not the one that we know and it intends to be a better one.
The Insigneo Institute at the University of Sheffield has the objective of creating an in silico
(computer simulated) replica of the human body that will enable the virtual testing of bespoke treatments.
By performing cycles of in silico
experiments and comparing them to the wetlab results, the discrepancies of the model and the actual organism are recognized.
Tokyo, Dec 19, 2013 - (JCN Newswire) - Fujitsu today announced that the University of Tokyo's Research Center for Advanced Science and Technology (RCAST) has selected Fujitsu's cloud service for analytical simulations, the FUJITSU Technical Computing Solution TC Cloud (TC Cloud), with the aim of accelerating research into new drugs using in silico
drug discovery(1) techniques.