They turned their attention to a family of transporter proteins called importins, which Prof.
For most of that time, he and his team have focused on the role of importins in nerve cells of the peripheral nervous system.
In a series of behavioral experiments, they then saw that mice lacking importin alpha-5 did not display anxiety under stress compared to normal littermates or those lacking other importins.
(2002) Ran GTPase cycle and importins [alpha] and [beta] are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.
(2008) Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells.
Then, we will address how these cargoes are transported from the cytoplasm to the nucleus and especially focus on one of the transport factors, importin [alpha].
Human importins and exportins are classified into four subfamilies.
However, the specificity of importins or exportins for each cargo would depend upon the structure and direct interaction of importin-cargo molecules.
The import-export machinery responsible for such translocation consists of importins and exportins.
It is then believed that the activated ligand-A-FABP complex interacts with nuclear importins
and the holo-A-FABP is translocated into the nucleus.
(2004) have found that 5-HT stimulation that produces LTF triggers the nuclear translocation of importins
, proteins involved in carrying cargos through nuclear pore complexes, in Aplysia sensory-motor neuron co-cultures.
fulfils a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains.