Imodium


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Related to Imodium: Motilium, Dafalgan

loperamide hydrochloride

Apo-Loperamide (CA), Arret (UK), Diah-Limit (UK), Diamode, Diaquitte (UK), Diareze (UK), Diarr-Eze (CA), Diarrhea Relief (CA), Diocalm Ultra (UK), Diocaps (UK), Dom-Loperamide (CA), Entocalm (UK), Imodium, Imodium A-D, K-Pek II, Loperacap (CA), Norimode (UK), Normaloe (UK), Novo-Loperamide (CA), PHL-Loperamide (CA), PMS-Loperamine (CA), Riva-Loperamine (CA), Sandoz Loperamide

Pharmacologic class: Piperidine derivative

Therapeutic class: Antidiarrheal

Pregnancy risk category B

Action

Inhibits peristalsis of intestinal wall musculature and intestinal contents. Also reduces fecal volume, increases fecal bulk, and minimizes fluid and electrolyte loss.

Availability

Capsules: 2 mg

Solution: 1 mg/5 ml

Tablets: 2 mg

Tablets (chewable): 2 mg

Indications and dosages

Acute diarrhea

Adults: Initially, 4 mg P.O., then 2 mg after each loose stool. Usual maintenance dosage is 4 to 8 mg P.O. daily in divided doses, not to exceed 16 mg daily.

Children ages 8 to 12 or weighing more than 30 kg (66 lb): Initially, 2 mg P.O. t.i.d., then 1 mg/10 kg after each loose stool, not to exceed 6 mg daily

Children ages 6 to 8 or weighing 20 to 30 kg (44 to 66 lb): Initially, 2 mg P.O. b.i.d., then 1 mg/10 kg after each loose stool, not to exceed 4 mg daily

Children ages 2 to 5 or weighing 13 to 20 kg (29 to 44 lb): Initially, 1 mg P.O. t.i.d., then 1 mg/10 kg after each loose stool, not to exceed 3 mg daily

Acute diarrhea (treated with over-the-counter loperamide)

Adults and children ages 12 and older: Two caplets with 4 to 8 oz water after first loose stool, then one caplet (with 4 to 8 oz water) after each subsequent loose stool. Don't exceed four caplets in 24 hours. Or give equivalent dosage in liquid form.

Children ages 9 to 11 who weigh 27 to 43 kg (60 to 95 lbs): One caplet with 4 to 8 oz water after first loose stool, then ½ caplet (with 4 to 8 oz water) after each subsequent loose stool. Don't exceed three caplets in 24 hours. Or give equivalent dosage in liquid form.

Children ages 6 to 8 who weigh 22 to 27 kg (48 to 59 lbs): One caplet with 4 to 8 oz water after first loose stool, then ½ caplet with 4 to 8 oz water after each subsequent loose stool. Don't exceed two caplets in 24 hours. Or give equivalent dosage in liquid form.

Children younger than age 6: Consult physician.

Chronic diarrhea

Adults: Initially, 4 mg P.O., then 2 mg after each loose stool; reduce dosage as tolerated. Don't exceed 16 mg daily for more than 10 days.

Contraindications

• Hypersensitivity to drug

• Abdominal pain of unknown cause (especially with fever)

• Acute diarrhea caused by enteroinvasive Escherichia coli, Salmonella, or Shigella

• Acute ulcerative colitis

• Bloody diarrhea with temperature above 38.3 °C (101 °F) (with OTC product)

• Pseudomembranous colitis associated with broad-spectrum anti-infectives

• Children younger than age 6

Precautions

Use cautiously in:

• hepatic disease

• elderly patients

• pregnant or breastfeeding patients

• children.

Administration

• Use patient's weight to determine appropriate dosage (especially in children).

Adverse reactions

CNS: drowsiness, dizziness

GI: nausea; vomiting; constipation; abdominal pain, distention, ordiscomfort; dry mouth; toxic megacolon (in patients with acute ulcerative colitis)

Other: allergic reactions

Interactions

Drug-drug. Antidepressants, antihistamines, other anticholinergics: additive anticholinergic effects

CNS depressants (including antihistamines, opioid analgesics, sedative-hypnotics): additive CNS depression

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

Watch for signs and symptoms of abdominal distention, which may signal toxic megacolon in patient with ulcerative colitis.

• Assess bowel movements to evaluate drug efficacy and determine need for repeat doses.

• Monitor stool cultures as indicated.

• Check stool for occult blood as indicated.

• Evaluate fluid intake and output.

• Stay alert for CNS effects, especially in children.

Patient teaching

• Stress importance of maintaining high fluid intake to prevent dehydration.

Instruct patient or parents to report fever, mucus in stool, or history of hepatic disease before using drug.

Caution patient or parents to discontinue drug if symptoms worsen or diarrhea lasts longer than 2 days.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Imodium

(ĭ-mō′dē-əm)
A trademark for the drug loperamide hydrochloride.

Imodium

A brand name for LOPERAMIDE.
References in periodicals archive ?
Healthcare company Perrigo Company plc (NYSE:PRGO) (TASE:PRGO) revealed on Friday the final approval from the US Food & Drug administration for the store brand over-the-counter (OTC) equivalent of Imodium Multi-Symptom Relief (loperamide hydrochloride and simethicone tablets) in 2 mg/125 mg.
windsurfing the bloodsuckers, up the and v off It's a good idea to take some Imodium tablets...
But Dr Rodgers told the inquest: "There was a very high level of loperamide, more commonly known as Imodium.
Two over-the-counter medications that can stop diarrhea are loperamide (Imodium) and bismuth subsalicylate (Kaopectate, Pepto-Bismol).
The Food and Drug Administration warned doctors and patients Tuesday that the over-the-counter and prescription medications, including Imodium, can cause potentially deadly heart problems when taken in large doses.
The company is present with a wide portfolio of digestive remedies, including popular brands, such as Vi-Siblin, Pepcid, Imodium and Microlax.
McNeil Consumer Healthcare remained the largest brand owner in digestive remedies in 2015 with a 22% value share, with brands such as Imodium, Pepcid and Lactaid, each of which is the leading brand in its respective category: diarrhoeal remedies, H2 blockers and digestive enzymes respectively.
You've packed all the important things - suncream, hat, Speedos, Imodium - but there's one thing you've got that you would never be without: your copy of the South Wales Echo.
Anti-diarrhoea medicines such as loperamide and Imodium, for example, are well known and can help reduce the impact.
We compared five named medicines - Panadol, Nurofen, Calpol, Imodium, and Anadin - with own-brand equivalents.
He said: "I took a headache tablet in case I hit the ground, wore some swimming trunks in case I fell in the water and took some Imodium just in case the worst happened.
One of these was loperamide, which is marketed as Imodium. The team selected this for an in vivo validation using a mouse model of Salmonella infection.