resTORbios lead program focuses on selective inhibition of the target of rapamycin complex 1 (TORC1) pathway to treat aging-related diseases with an initial focus on diseases caused by immunosenescence
, the decline in immune function that occurs during aging.
describes the decline in immune defences that leads to increased risk of infection, poor wound healing and reduced responses to vaccination in older adults.
, the age-dependent decline in immune function, is associated with a decreased ability to fight infections such as respiratory tract infections in the elderly.
HIV infection, inflammation, immunosenescence
, and aging.
The role of oxidative and inflammatory stress and persistent viral infections in immunosenescence
Under the agreement PureTech Health will develop these new product candidates in an operating subsidiary, resTORbio, with an initial focus on diseases related to immunosenescence
, an age-related decline in immune function.
Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence
22) The incidence of zoster increases substantially with age, again as a result of increasing immunosenescence
8, 9, 22] Deterioration of immunity is common in the aging population, which is scientifically known as immunosenescence
An evolutionary perspective on immunosenescence
," Annals of the New York Academy of Sciences, vol.
It can be concluded that the resistance exercise can cause acute change in the serum of interleukin 6 and tumor necrosis factor alpha, so exercise is important for the prevention and treatment of several diseases, in particular diseases that affect the elderly, helps maintain or improve muscle volume, reduce low-grade inflammation, attenuates sarcopenia and immunosenescence
Deeks, HIV Infection, Inflammation, Immunosenescence