AIP(redirected from Immunophilin homolog ARA9)
AIP(1) A 330 residue protein that helps stabilise the AIP-hsp90-AhR complex and protects the AhR receptor from ubiquitination under heat-stress conditions; AIP may also play a role in regulating the rate of AhR turnover by delaying AhR nuclear translocation after ligand binding.
(2) A gene on chromosome 11q13.3 that encodes a receptor for aryl hydrocarbons and a ligand-activated transcription factor. It resides in the cytoplasm as part of a multiprotein complex and is transported to the nucleus once it binds with a ligand. AIP regulates the expression of many xenobiotic metabolising enzymes; it binds specifically to and inhibits the activity of hepatitis B virus.
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AIPAcute intermittent porphyria
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.