immunologically privileged sites

im·mu·no·log·i·cal·ly priv·i·leged sites

sites where allografts are not readily rejected or tumors escape immune surveillance probably because these particular areas have poor lymphatic drainage, are not readily accessible to effector cells of the immune system, for example, central nervous system or involve immune-tolerance mechanisms.
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As the acute Ebola epidemic in West Africa flickers out (42 days having passed, at the time of writing, without a fresh infection in two of the three countries affected), it was dismaying to learn that the infection has reared its ugly head again: in the case of volunteer Scottish nurse Pauline Cafferkey (reminding us of the virus's tendency to hide in immunologically privileged sites, [8] raising the spectre of unrecognised complications among survivors in countries in which healthcare services were decimated by the outbreak), and a few new cases in Guinea.
Such research is crucial, since limited CTL activity at mucosal surfaces could be a built-in mechanism to protect the mucosal epithelium from damage, a notion supported by the observation that pCTL in immunologically privileged sites fail to differentiate into fully functional CTL, unless exposed to antigen (40).
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