class switching

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class switching

Physiology A step in the normal maturation of Hb during fetal development that requires switching from embryonal zeta chain, which is structurally similar to the α chain, and occurs on chromosome 16 to mature α chain production; β chain production is a 2-stage maturation process with early loss of the ε chain and the presence during fetal and early post-natal life of a γ chain, which ↓ as β chain expression is ↑. See Introduction to this volume: note.

class switching

The change, by a B cell, of the class of an antibody it produces (for example from IgM to IgG) without a change in its specificity.
References in periodicals archive ?
Murine PTEN-deficient B cells were resistant to apoptotic and migratory stimuli and demonstrated defective immunoglobulin class switching, emphasizing a role for PTEN in the regulation of B cells [21].
(10) The latter involves studies that evaluate in vitro immunoglobulin biosynthesis induced by specific stimuli that may include selected cytokines to induce immunoglobulin class switching. The interpretation of these tests should be done by a clinical immunologist and must be considered in the context of the clinical story and the standard testing used to assess humoral immunity.