immunological tolerance

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Related to Immune tolerance: hypersensitivity, autoimmunity

immunological tolerance

The state in which the immune system does not react to the body's own antigens. It is caused by the destruction of lymphocytes that express receptors to autoantigens as they develop. Failure of these mechanisms may result in autoimmune disease.
See also: tolerance

immunological tolerance

the failure to respond to a potential antigen.


the ability to endure without effect or injury.

drug tolerance
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
high-dose tolerance
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
immunological tolerance
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
tolerance level
the concentration of a drug or chemical permitted by law to be present in human food.
tolerance limits
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
low-dose tolerance
that induced by repeated administration of low doses of the antigen.
oral tolerance
that induced by oral administration of the antigen.
the non-reactivity of the immune system to self-antigens.
tolerance test
see tolerance test.
zero tolerance
when no detectable amount of a chemical substance is permitted in human food.
References in periodicals archive ?
Recent studies of immune tolerance have focused on the role of a subset of T cells, called regulatory T cells or Tregs.
Other projects include a registry that tracks the outcomes of islet transplants and a research group that is testing ways to induce immune tolerance in non-human primate models of kidney and islet transplantation.
The products resulting from this collaboration will leverage Selecta's proprietary Synthetic Vaccine Particle (SVP[TM]) platform which has unique capabilities to engineer nanoparticles with the ideal structure and composition to produce immune tolerance by balancing the overactive response to specific allergy-causing antigens.
Unlike current MS therapies that non-discriminately suppress the entire immune system, this study highlights the effectiveness of an antigen-coupled nanoparticle treatment that stimulates immune tolerance to myelin only, halting the autoimmune attacks in animal MS models.
Getts continued, "Along with Steve Miller at Northwestern University and Lonnie Shea at the University of Michigan, we've combined discoveries on immune tolerance and immune system modulation with novel bioengineered nanoparticles creating a broad platform of antigen specific nanoparticle therapies we believe will be transformational for celiac and other immune diseases.
Kenneth Newell led the study, performed by the Immune Tolerance Network (ITN), an international research consortium with headquarters at University of California, San Francisco.
Rhitol(TM) treatment targets activated T cells that cause GvHD and results in immune modulation within patients with chronic GvHD, restores immune tolerance and attempts to achieve disease remission.
The trial is being funding by the Immune Tolerance Network.
Immune tolerance is a poorly understood mechanism by which the body, when exposed to large amounts of foreign material, comes to accept it rather than reject it.
Immune tolerance therapy with octanate[R] has shown to be highly successful in inhibitor elimination, even in patients with poor prognosis.
They note that estrogen can directly modulate the immune response, which could complete the action of some sex-linked genes and contribute to the genetic predisposition of the disease, and it has also been shown to have an effect on the breakdown of immune tolerance seen in SLE.
AC Immune's proprietary immunology platform technology brings the ability to break the immune tolerance to "self" proteins by generating conformation-sensitive antibodies that lead to the creation of active and passive immune therapies.

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