immunological tolerance

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Related to Immune tolerance: hypersensitivity, autoimmunity

immunological tolerance

The state in which the immune system does not react to the body's own antigens. It is caused by the destruction of lymphocytes that express receptors to autoantigens as they develop. Failure of these mechanisms may result in autoimmune disease.
See also: tolerance

immunological tolerance

the failure to respond to a potential antigen.


the ability to endure without effect or injury.

drug tolerance
1. decreased susceptibility to the effects of a drug due to its continued administration.
2. the maximum permissible level of a drug in or on animal feed or food at any particular time relative to slaughter.
high-dose tolerance
in immunology, that induced by the intravenous administration of high doses of aqueous proteins.
immunological tolerance
specific nonreactivity of the immune system to a particular antigen, which is capable under other conditions of inducing an immune response. There is, under normal circumstances, tolerance to self-antigens; identical (monozygotic) twins and dizygotic cattle or sheep twins where there has been placental fusion and exchange of bone marrow stem cells are also tolerant of each other's tissues. Allophenic mice, that is mice produced by fusion of blastocysts from different mice are also tolerant of both 'parents'. The administration of antigens either at high or low dose and infection with certain viruses during critical early stages of immunological development may also induce tolerance.
tolerance level
the concentration of a drug or chemical permitted by law to be present in human food.
tolerance limits
the numerical limits within which a previously identified proportion of values of a variable, or observations in a population, can be expected to occur.
low-dose tolerance
that induced by repeated administration of low doses of the antigen.
oral tolerance
that induced by oral administration of the antigen.
the non-reactivity of the immune system to self-antigens.
tolerance test
see tolerance test.
zero tolerance
when no detectable amount of a chemical substance is permitted in human food.
References in periodicals archive ?
The cutoff value of 36 years might be mainly related to mother-to-child transmission which resulted in relatively an immune tolerance period of up to 30 years in treatment-naAaAaAeA ve HBeAg-positive chronic HBV-infect patients in China.
Similar to the results reported previously that CD4+ T cells from the tolerant mice could transfer tolerance [5], we found that this long-lasting immune tolerance could also be transferred to syngeneic naive C3H mice through adoptive transfer of CD4+ T cells from the tolerant mice, demonstrating that CD4+ T cells from tolerant mice markedly suppressed alloantigen-induced anti-donor antibody development compared to CD4+ T cells transferred from immunized mice (Figures 2(a), 2(b), and 2(c)).
Based on the prominence of high somatic hypermutation in these antibody gene sequences, it was earlier postulated that anti-DNA lupus B-cell clones are the products of germinal center (GC) responses in peripheral lymphoid tissues suggesting that SLE is associated with a defect in peripheral immune tolerance.
Applied Biosystems and the Immune Tolerance Network signed a multi-year agreement to study genes expressed in clinical samples related to immune response modulation inorgan transplantation, autoimmune disease, andallergy and asthma.
This issue has made it imperative that solutions to the shortage be investigated, including xenotransplantation, gene therapy, immune tolerance, and the use of implantable artificial organs.
The results of the pilot were sufficiently encouraging that the Immune Tolerance Network is organizing an expanded study in which Shapiro and his colleagues will cooperate over an 18-month period with investigators from seven other institutions around the world.
The Immune Tolerance Network is now recruiting Type 1 patients for the second study, a clinical trial of the promising Edmonton protocol for islet transplantation (see "One Step Closer to a Cure," September/October 2000 Saturday Evening Post, and "Diabetes: Closer to a Cure," July 2000 Medical Update).
Investigators new to immune tolerance are particularly encouraged to develop projects in this area.
Eligix is a privately held biomedical company engaged in the development of transplantation and immune therapies for the treatment of cancers and infectious diseases and for achieving immune tolerance to transplanted organs.
Immune cells CB immune cell immaturity, T helper cells, T regulatory cells, neonatal immune tolerance, natural killer cells and T-cell-dependent immune competence.
ILDR2-Fc has a unique mechanism of action underlying its ability to ameliorate autoimmunity, which combines immunomodulation with regulation of immune homeostasis and with re-establishment of immune tolerance.

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