immune complex glomerulonephritis


Also found in: Acronyms.

im·mune com·plex glo·mer·u·lo·ne·phri·tis

immune complexes are deposited in the renal glomerulus where they bind complement and initiate an inflammatory process, attracting neutrophils and macrophages, resulting in an alteration of the basement layer of the kidney. The disease state can lead to ultimate destruction of the glomerulus and renal failure.
References in periodicals archive ?
HIV-associated immune complex glomerulonephritis with "lupus-like" features: a clinicopathologic study of 14 cases.
The observations correlated well with proteinuria findings and were consistent with early appearance of immune complex glomerulonephritis in chlordecone-treated mice.
There is a consensus among renal pathologists that immune complex deposition is a diffuse phenomenon, meaning that if immune complex glomerulonephritis occurs, all glomeruli with open capillaries will show immune complex deposits, even if the light microscopic lesions are focal (in many glomerulonephritides not all glomeruli show light microscopic abnormalities).
Specifically, estrogen has been linked with the risk of developing systemic lupus, scleroderma, and Raynaud disease (Mayes 1999); solvents linked with systemic sclerosis and scleroderma (Mayes 1999); mercuric chloride linked with immune complex glomerulonephritis (Mayes 1999; Powell et al.

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