Ramu, Docking of Ethanamine Schiff Base Imines
and Metal (II) Complexes, Cytotoxicity and DNA Interaction Studies, J.
The experimental procedure reported here for synthesis of 2-azetidinones 2a-q involves the cyclocondensation reaction of imines
1a-q with monochloroacetyl chloride in presence of Et3N using 2-methoxyethanol as a novel and ecofriendly solvent under microwave irradiation (Scheme 1, Table 1).
The IR spectra for imine
compounds 8a-g showed characteristic absorption peak in the range of (1588-1638 [cm.sup.-1]) stretching for (C=N), at (1695-1722 [cm.sup.-1]) stretching group for (C=O) group of lactones' ring.
Caption: Figure 10: Proposed mechanism for the formation of an imine
as a by- product of the polymerization process.
We have recently reported the synthesis and characterization of a series of novel 5-phenylpyrazolidin-3-one-based azomethine imines
, including photochromic compounds and systems sensitive to cations and anions [32, 33].
L-Cys reacts with acetaldehyde to generate imine
(Figure 6), which is harmless to the human body and can be directly excreted, making L-Cys protective to organisms [20, 25].
For example; bioactivation of acetaminophen by CYP2E1 leads to the formation of the toxic metabolite N-acetyl-p-benzoquinone imine
The main groups of identified compounds are; (1) carboxylic acids and esters (2) hydrocarbons and derivatives (3) imines
amines and amides derivatives (4) alcohol derivatives (5) phenol derivatives (6) heterocyclic aromatic compounds (7) benzene derivatives (8) ketone derivatives (9) cyclodienes (10) azole derivatives (11) aldehyde derivatives and (12) diphenyl ether derivatives.
The method claimed for imparting nonvolatility to the smelly aldehydes was the facile reaction of the carbonyl groups thereof with primary amines to form imines
. The listing of suitable amines included chitosan, a natural, film-forming aminopolysacch a ride, now commercially manufactured worldwide from shrimp shells.
* [.sup.1]H-NMR (DMSO-[d.sub.6], TMS): [delta], 1.22-2.87 (methylene protons), 6.86-8.47 (aromatic ring protons), 9.77 (imines
protons), and 10.06 (urethanes protons).
Among the methods reported for the synthesis of [alpha]-aminonitriles, nucleophilic addition of cyanide ion to imines
(Strecker reaction) is of great importance to modern organic chemistry as it offers one of the most direct and viable methods for the synthesis of [alpha]-aminonitriles .
Miyoshi's group has previously reported the successful use of metallic strontium to obtain high yields in the alkylation of aldehydes or imines
with alkyl iodides1,2 and dialkylation of esters with alkyl iodides3.