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Inhibition of JAK1 modulates multiple cytokines involved in pathophysiology of AD including interleukin -4, IL-13, IL-31 and interferon gamma.
At this dosage the IL-31 receptor is saturated, so higher dosages aren't needed," Dr.
It works by mimicking the activity of natural antibodies to selectively bind and neutralize IL-31, thus interrupting the itch cycle in atopic dogs.
IL-31 has been identified as a pruritogenic cytokine1), and reported to be involved in the generation of pruritus in atopic dermatitis and hemodialysis2,3).
The imbalance in T-cell subsets in AD--predominantly TH2--results in expression of IL-4, IL-5, and IL-13, as well as so-called "pruritus-specific" cytokine IL-31.
Posee una estructura helicoidal y comparte similitudes con otras citocinas: IL-11, factor inhibidor de la leucemia, factor neurotropico ciliar, oncostatina M, cardiotropina-1 y la citocina similar a cardiotropina, IL-27, IL-31, neurotropina-1/factor 3 estimulador de celulas B (4,8,9,22).
2]) response, including IL-4/ IL-13 receptor [alpha] chain, IL-13 alone, IL-22, and IL-31.
H]2) response, including IL-4/IL-13 receptor [alpha] chain, IL-13 alone, IL-22, and IL-31.
In addition, IL-31 has been identified as a unique [T.
It acts rapidly (within 1 day for many dogs) and prevents binding of IL-31 to its neuronal receptor for at least a month, thereby interrupting neurotransmission of itch.
28-29) IL-31 is also an important regulator of keratinocyte differentiation and filaggrin expression.
17) Research suggests that IL-31 increases epidermal basal-cell proliferation and thickening of the epidermal skin layer, resulting in transepidermal water loss.
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- IL-2/LAK cells
- IL-23 subunit alpha
- IL-27 p28 subunit
- IL-27 subunit alpha
- IL-2R subunit alpha
- IL-2R subunit gamma
- IL-4 receptor subunit alpha
- IL-4 Stat
- IL-4-induced secreted protein
- IL-4R subunit alpha
- IL-8 receptor type 1