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Kotenko is being honored for his seminal co-discovery and cloning of the type III interferons (IFN lambda1, 2, and 3 or IL-29, IL-28A and B) and their receptors; this work was published in Nature Immunology.
The company completed start-up of its pilot-scale protein manufacturing facility and began GMP manufacturing of IL-29 to supply clinical trials planned for 2006.
Advancement of both TACI-Ig and IL-21 into Phase 2 studies, and the start of IL-29 clinical testing, will make 2006 a very important year for the company's long-term success.
IL-29 is being manufactured in ZymoGenetics' pilot scale manufacturing facility in Seattle, Washington.
IL-29 is generated in response to viral infection and preclinical data has shown anti-viral activity comparable to that of alpha-interferon.
PEG-Interferon lambda is a member of the Type III lambda interferon family, which includes IL-28A, IL-28B and IL-29 (also known as interferon lambda 2, 3, and 1, respectively).
IL-29 is a member of the type 3 Interferon family, which includes IL-28A and IL-28B, and signals through the same receptor as IL-28A and IL-28B.
SEATTLE -- Pipeline expands to include IL-29, potential treatment for Hepatitis C, as fourth product candidate; Important clinical milestones also reported
These included a milestone payment from Novo Nordisk related to the start of IL-21 clinical trials outside North America; fees earned from Novo Nordisk related to the license of IL-28, IL-29 and IL-31 outside North America; and continued recognition of IL-20 license fee revenue received from Novo Nordisk earlier this year.
future genomics-derived protein development candidates such as IL-29 and
IL-28A and IL-29 show potential in providing immunity to viral infection, and Interleukin 31 (IL-31) is believed to play a role in stimulating cellular infiltration and inflammation.
role of a family of novel cytokines, IL-28, IL-29 and IL-28
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- IL-2 receptor
- IL-2 receptor subunit alpha
- IL-2 receptor subunit gamma
- IL-2/LAK cells
- IL-23 subunit alpha
- IL-27 p28 subunit
- IL-27 subunit alpha
- IL-2R subunit alpha
- IL-2R subunit gamma
- IL-4 receptor subunit alpha
- IL-4 Stat
- IL-4-induced secreted protein
- IL-4R subunit alpha