IL29

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IL29

A gene on chromosome 19q13.13 that encodes interleukin-29, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL29 is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway.
References in periodicals archive ?
Human IL-28A, IL-28B, and IL-29, also known as interferon (IFN)-[lambda]2, -[lambda]3 and -[lambda]1, respectively, belonging to the type III IFNs.
28-30) As type III IFNs including IL-28A, IL-28B and IL-29 are frequently upregulated in response to certain types of virus infections and exerted antiviral activity in vitro.
The product is a member of the Type III lambda interferon family, which includes IL-28A, IL-28B and IL-29, stated the partnership.
Kotenko is being honored for his seminal co-discovery and cloning of the type III interferons (IFN lambda1, 2, and 3 or IL-29, IL-28A and B) and their receptors; this work was published in Nature Immunology.
PEG-Interferon lambda is a member of the Type III lambda interferon family, which includes IL-28A, IL-28B and IL-29 (also known as interferon lambda 2, 3, and 1, respectively).
IL-29 is a member of the type 3 Interferon family, which includes IL-28A and IL-28B, and signals through the same receptor as IL-28A and IL-28B.
SEATTLE -- Pipeline expands to include IL-29, potential treatment for Hepatitis C, as fourth product candidate; Important clinical milestones also reported
Also, our pipeline is expanding with the addition of IL-29 as a potential treatment for hepatitis C," added Dr.
These included a milestone payment from Novo Nordisk related to the start of IL-21 clinical trials outside North America; fees earned from Novo Nordisk related to the license of IL-28, IL-29 and IL-31 outside North America; and continued recognition of IL-20 license fee revenue received from Novo Nordisk earlier this year.
future genomics-derived protein development candidates such as IL-29 and
IL-28A and IL-29 show potential in providing immunity to viral infection, and Interleukin 31 (IL-31) is believed to play a role in stimulating cellular infiltration and inflammation.