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Injections of IL-27 after a hemorrhage helped mice recover.
Recently, IL-27 was proven to possess multifaceted anti-tumor activity in lung (15), prostate (16), pancreatic (17) and breast cancers (18).
Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease.
However, the involvement of IL-27 in malignant pleural effusion (MPE) remains unknown.
Interferon gamma (INF-) produces IL-27 in target tissue and therefore alleviates uveitis by antagonising Th-17.
2-4) IL-27 consists of EBI3 (an IL-12p40 related protein) and p28 (an IL-12p35 related subunit).
Along with his research colleagues, he will also look at whether a molecule called IL-27 has the potential to predict and prevent the development of these immune cell clusters, and explore which current treatments are the most successful at blocking their formation.
1] contribute to our knowledge on NF-[kappa]B and cytokines IL-18 and IL-27 in experimental AP at 6 h, 12 h, 24 h and 48 h after IFN-[gamma] treatment.
Scientists used to think IL-27 played a role in causing inflammation, but, in 2005, a team of Penn researchers, including Hunter, found the opposite; it was actually involved in suppressing inflammation.
Posee una estructura helicoidal y comparte similitudes con otras citocinas: IL-11, factor inhibidor de la leucemia, factor neurotropico ciliar, oncostatina M, cardiotropina-1 y la citocina similar a cardiotropina, IL-27, IL-31, neurotropina-1/factor 3 estimulador de celulas B (4,8,9,22).
21,23) Indeed, IL-12 and related cytokines (IL-23, IL-27, and IL-1) are primarily released by infected DC very early on post infection by Leishmania, thus efficiently inducing Th1-mediated protection.
IL-27 is a protein belonging to a large family of molecules called cytokines which send signals between cells.
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- IL-2 receptor
- IL-2 receptor subunit alpha
- IL-2 receptor subunit gamma
- IL-2/LAK cells
- IL-23 subunit alpha
- IL-27 p28 subunit
- IL-27 subunit alpha
- IL-2R subunit alpha
- IL-2R subunit gamma
- IL-4 receptor subunit alpha
- IL-4 Stat
- IL-4-induced secreted protein
- IL-4R subunit alpha