IL27

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IL27

A gene on chromosome 16p11 that encodes interleukin-27, a pro- and anti-inflammatory cytokine that regulates T-helper cell development, suppresses T-cell proliferation, stimulates cytotoxic T-cell activity, induces isotype switching in B-cells, and which has diverse effects on innate immune cells. Its target cells include CD4 T-helper cells, which can differentiate in types 1 and 2 effector cells (TH1 and TH2), and IL17-producing helper T-cells (TH17); it drives rapid clonal expansion of naïve CD4 T-cells. It strongly synergises with IL12 to trigger interferon-gamma production by naïve CD4 T-cells and binds to the cytokine receptor WSX-1/TCCR, which appears to be required for IL27-mediated signal transduction. IL27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It also has antitumour and antiangiogenic activity, with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. IL27 is also a less preferred gene symbol for what is now designated as IL17D, see there.
References in periodicals archive ?
Injections of IL-27 after a hemorrhage helped mice recover.
Recently, IL-27 was proven to possess multifaceted anti-tumor activity in lung (15), prostate (16), pancreatic (17) and breast cancers (18).
Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease.
However, the involvement of IL-27 in malignant pleural effusion (MPE) remains unknown.
Interferon gamma (INF-) produces IL-27 in target tissue and therefore alleviates uveitis by antagonising Th-17.
2-4) IL-27 consists of EBI3 (an IL-12p40 related protein) and p28 (an IL-12p35 related subunit).
Along with his research colleagues, he will also look at whether a molecule called IL-27 has the potential to predict and prevent the development of these immune cell clusters, and explore which current treatments are the most successful at blocking their formation.
1] contribute to our knowledge on NF-[kappa]B and cytokines IL-18 and IL-27 in experimental AP at 6 h, 12 h, 24 h and 48 h after IFN-[gamma] treatment.
Scientists used to think IL-27 played a role in causing inflammation, but, in 2005, a team of Penn researchers, including Hunter, found the opposite; it was actually involved in suppressing inflammation.
Posee una estructura helicoidal y comparte similitudes con otras citocinas: IL-11, factor inhibidor de la leucemia, factor neurotropico ciliar, oncostatina M, cardiotropina-1 y la citocina similar a cardiotropina, IL-27, IL-31, neurotropina-1/factor 3 estimulador de celulas B (4,8,9,22).
21,23) Indeed, IL-12 and related cytokines (IL-23, IL-27, and IL-1) are primarily released by infected DC very early on post infection by Leishmania, thus efficiently inducing Th1-mediated protection.
IL-27 is a protein belonging to a large family of molecules called cytokines which send signals between cells.