IL17A

(redirected from Il-17)
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to Il-17: IL-2, IL-23

IL17A

A gene on chromosome 6p12 that encodes interleukin-17A, a proinflammatory cytokine produced by activated T cells which regulates NF-kappaB and mitogen-activated protein kinases. It upregulates IL6 and cyclooxygenase-2 and increases nitric oxide production.

Molecular pathology
IL17A is overexpressed in rheumatoid arthritis, psoriasis and multiple sclerosis.
References in periodicals archive ?
In the present study, we found that exposure to radiation increased the levels of IFN-[gamma], TNF-[alpha], IL-6, and IL-17, and decreased the levels of IL-10.
The special human kit for measuring IL-17 serum level (eBioscience, USA) and an ELISA equipment (Elisa Awareness, USA) were used to determine IL-17 serum levels.
A greater number of IL-17 mRNA expressing cells were found by using in situ hybridization in cerebrospinal fluid than in peripheral blood from patients with MS.
Intracellular staining with antibodies against IL-17 (BD Biosciences) was performed and analyzed by flow cytometry.
Conclusion: All these results showed that IFN-[gamma], TNF-[alpha], IL-23, IL-17 and OPN levels increase both in lesion and serum in psoriasis patients, however, further investigation should be made in order to assess their role in the immunopathogenesis of psoriasis and their relationship with the disease and comorbidities.
MCP-1 was completely dependent on Nlrp3; IL-17 was completely dependent on caspase1, Nlrp3, and partially dependent on ASC; and C3a was partially dependent on Nlrp3 inflammasome.
RA'da, TNF-alfa, IL-1, IL-6, IL-15, IL-17 ve IL-18 gibi proenflamatuvar sitokinlerin yani sira, otoantikorlar, prostoglandinler, nitrik oksit ve kompleman gibi patojenik mediyatorler ortama salinir.
That B cells may contribute to the inhibition of IL-17 production is not unexpected, because Th17 cells have been implicated in several autoimmune diseases.
Genentech brings an in-depth understanding of IL-17 biology and extensive experience in its ability to potentially identify patient populations that may benefit from such a compound thus maximizing chances of successful development.
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.
Durelli presented an Italian multicentre study which showed that interleukin IL-17 and IL-22 were increased in MS relapses and their specificity for a myelin antigen suggests that it may be encephalitogenic.