NFKBIA

(redirected from IkappaBalpha)

NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.
Vitamin D decreases NFkappaB activity by increasing IkappaBalpha levels.
Rea et al., "Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclastlike cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades," Journal of Cellular Physiology, vol.
Hay, "SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation," Molecular Cell, vol.
Chen et al., "MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IkappaBalpha both in vitro and in vivo," Neuro-Oncology, vol.
Ghoda, "Modulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors," BMC Immunology, vol.
Huang, "The IkappaBalpha gene is a peroxisome proliferator-activated receptor cardiac target gene," The FEBS Journal, vol.
indicated gum mastic significantly potentiated antiproliferative and apoptotic effects of gemcitabine in both pancreatic cancer BxPC-3 and COLO 357 cells by increasing the expression of IkappaBalpha and Bax protein, blocking NF-kappaB activation and downregulating the expression of Bcl-2 protein [28].
Specifically, aucubin was demonstrated to inhibit antigen-induced nuclear translocation of p65 subunit of NF-kappaB, (17) and the subsequent degradation of IkappaBalpha, thus preventing the activation of NF-kappaB, and in turn resulting in a decrease in inflammation.
Core event extraction, as shown in the first row of Table 8, includes trigger detection (Expression), event typing (Gene_expression:Expression), primary argument recognition (IkappaBalpha), and finally frame filling (E1 event_type:event trigger Theme:primary argument).