Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha
levels in rat skeletal muscle in a fiber-type dependent manner.
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha
kinase and Akt activation.
Vitamin D decreases NFkappaB activity by increasing IkappaBalpha
Rea et al., "Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclastlike cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha
signaling cascades," Journal of Cellular Physiology, vol.
Constitutive degradation of IkappaBalpha
in human T lymphocytes is mediated by calpain.
Hay, "SUMO-1 modification of IkappaBalpha
inhibits NF-kappaB activation," Molecular Cell, vol.
Chen et al., "MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IkappaBalpha
both in vitro and in vivo," Neuro-Oncology, vol.
Ghoda, "Modulation of p53 activity by IkappaBalpha
: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors," BMC Immunology, vol.
Huang, "The IkappaBalpha
gene is a peroxisome proliferator-activated receptor cardiac target gene," The FEBS Journal, vol.
indicated gum mastic significantly potentiated antiproliferative and apoptotic effects of gemcitabine in both pancreatic cancer BxPC-3 and COLO 357 cells by increasing the expression of IkappaBalpha
and Bax protein, blocking NF-kappaB activation and downregulating the expression of Bcl-2 protein .
Specifically, aucubin was demonstrated to inhibit antigen-induced nuclear translocation of p65 subunit of NF-kappaB, (17) and the subsequent degradation of IkappaBalpha
, thus preventing the activation of NF-kappaB, and in turn resulting in a decrease in inflammation.
Core event extraction, as shown in the first row of Table 8, includes trigger detection (Expression), event typing (Gene_expression:Expression), primary argument recognition (IkappaBalpha
), and finally frame filling (E1 event_type:event trigger Theme:primary argument).