IgA nephropathy

(redirected from IgA nephritis)


1. any disease of the kidneys. adj., adj nephropath´ic.
2. any disease of the kidneys; see also nephritis. Called also nephrosis. adj., adj nephropath´ic.
AIDS nephropathy former name for HIV-associated nephropathy.
analgesic nephropathy interstitial nephritis with renal papillary necrosis, seen in patients with a history of abuse of analgesics such as aspirin or acetaminophen alone or in combination.
diabetic nephropathy the nephropathy that commonly accompanies later stages of diabetes mellitus; it begins with hyperfiltration, renal hypertrophy, microalbuminuria, and hypertension; in time proteinuria develops, with other signs of decreasing function leading to end-stage renal disease.
gouty nephropathy any of a group of chronic kidney diseases associated with the abnormal production and excretion of uric acid.
heavy metal nephropathy the kidney damage resulting from any of various forms of heavy metal poisoning, usually in the form of tubulointerstitial nephritis. The most common metals involved are cadmium, lead, and mercury.
HIV-associated nephropathy renal pathology in patients infected with the human immunodeficiency virus, similar to focal segmental glomerulosclerosis, with proteinuria, enlarged kidneys, and dilated tubules containing proteinaceous casts; it may progress to end-stage renal disease within weeks.
hypokalemic nephropathy nephropathy with hypokalemia, interstitial nephritis, swelling and vacuolization of proximal renal tubules, and progressive renal failure, resulting from conditions such as oncotic overloading of the kidney filtration mechanisms by sugars. See also potassium-losing nephropathy.
IgA nephropathy a chronic form marked by hematuria and proteinuria and by deposits of IgA immunoglobulin in the mesangial areas of the renal glomeruli, with subsequent reactive hyperplasia of mesangial cells. Called also Berger's disease and IgA glomerulonephritis.
ischemic nephropathy nephropathy resulting from partial or complete obstruction of a renal artery with ischemia, accompanied by a significant reduction in the glomerular filtration rate.
lead nephropathy the kidney damage that accompanies lead poisoning; lead deposits appear in the epithelium of the proximal tubules and as nuclear inclusions in cells. In time this leads to tubulointerstitial nephritis with chronic renal failure and other symptoms.
membranous nephropathy membranous glomerulonephritis.
minimal change nephropathy minimal change disease.
obstructive nephropathy nephropathy caused by obstruction of the urinary tract (usually the ureter), with hydronephrosis, slowing of the glomerular filtration rate, and tubular abnormalities.
potassium-losing nephropathy hypokalemic nephropathy after persistent potassium loss; it may be seen in metabolic alkalosis, adrenocortical hormone excess, or in intrinsic renal disease such as renal tubular acidosis or hyperplasia of juxtaglomerular cells. Called also potassium-losing nephritis.
reflux nephropathy childhood pyelonephritis in which the renal scarring results from vesicoureteric reflux, with radiological appearance of intrarenal reflux.
salt-losing nephropathy intrinsic renal disease causing abnormal urinary sodium loss in persons ingesting normal amounts of sodium chloride, with vomiting, dehydration, and vascular collapse. Called also salt-losing nephritis.
urate nephropathy (uric acid nephropathy) any of a group of kidney diseases occurring in patients with hyperuricemia, including an acute form, a chronic form (gouty nephropathy), and nephrolithiasis with formation of uric acid calculi.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

fo·cal glo·mer·u·lo·ne·phri·tis

glomerulonephritis affecting a small proportion of renal glomeruli that commonly presents with hematuria and may be associated with acute upper respiratory infection in young males, not usually due to streptococci; associated with IgA deposits in the glomerular mesangium and may also be associated with systemic disease, as in Henoch-Schönlein purpura.
Farlex Partner Medical Dictionary © Farlex 2012

IgA nephropathy

Berger's disease, IgA glomerulonephritis Nephrology Idiopathic IgA nephropathy is the most common form of primary glomerulonephritis in the world; primary IN is mediated by immune complexes and defined immunohistochemically by glomerular deposition of IgA; in 20-40% of Pts, it progresses to renal failure 5-25 yrs after diagnosis; IN may occur in HIV-infected Pts Clinical Macroscopic hematuria which may coincide with an URI and be accompanied by flank pain, a presentation typical of younger Pts; older Pts tend to be asymptomatic and IN is detected by sediment and proteinuria Treatment ACE-inhibitors, corticosteroids, n-3 polyunsaturated fatty acids provided in dietary fish oil may slow progression of renal failure, kidney transplantation Prognosis More rapid progression occurs in ♂, older Pts, HTN, persistent proteinuria, baseline of impaired renal function, glomerulosclerosis or interstitial fibrosis at the time of initial evaluation
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

IgA nephropathy

A form of GLOMERULONEPHRITIS associated with deposition of the immunoglobulin IgA in the glomeruli of the kidneys. There is occasional blood and protein in the urine and kidney failure may occur. The cause is unknown and there is no effective treatment.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
[8] Signs in the renal biopsy of IgA vasculitis are the same as those of IgA nephritis. [9] The etiology of IgA vasculitis is yet to be determined; however, there are often precipitating factors, such as infectious diseases, a reaction to drugs or malignancy.
Henoch-Schonlein purpura (HSP) is a systematic vasculitis presenting primarily in children, but less so in adults, often resulting in IgA-associated vasculitis in skin and IgA nephritis [1, 2].
New subgroup of primary IgA nephritis with thin glomerular basement membrane (GBM): syndrome or association.
Ponticelli, "Tonsillectomy and IgA nephritis," Nephrology Dialysis Transplantation, vol.
Pathological Diagnosis Male Female Percentage Lupus Nephritis 4 44 36.1% Focal Segmental Glomerulosclerosis 11 15 19.5% Membranous Glomerulopathy 8 5 9.8% Chronic Glomerulonephritis 6 4 7.5% Mesangial Proliferative 2 4 4.5% Glomerulonephritis Diabetic Glomerulonephritis 4 1 3.8% IgA Nephritis 2 2 3.0% Acute Proliferative Glomerulonephritis 3 1 3.0% Membranoproliferative Glomerulonephritis 1 2 2.3% Acute Tubular Necrosis 0 3 2.3% Amyloidosis 2 1 2.3% Focal Proliferative Glomerulonephritis 0 2 1.5% Crescentic Glomerulonephritis 2 0 1.5% Tubulo-Interstitial Nephritis 1 1 1.5% Thrombotic Microangiopathy 2 0 1.5% Total 48 85 Table 2: Spectrum of pathological diagnosis by decades.
Coun Sharpe has suffered from IgA nephritis - a progressive inflammatory disease of the kidneys - for the past 16 years.
(6) Glomerular C4d deposition has been reported in normal kidney tissue, lupus nephritis, IgA nephritis, membranous glomerulopathy, membranoproliferative glomerulonephritis, and in a case of pre-eclampsia.
RA is an autoimmune systemic disease, and the most common renal disorders associated with RA or drugs used in treatment such as NSAIDs and disease-modifying antirheumatic drugs (DMARDs) are secondary amyloidosis, rheumatoid vasculitis, analgesic nephropathy and drug-induced membranous nephropathy, especially gold salt and penicillamine; [sup][2] however, IgA nephritis associated with RA was quite rare and there are no reports of crescentic IgA nephritis secondary to the use of NSAIDs or DMARDs.