idiotypes


Also found in: Dictionary, Encyclopedia.

idiotypes

The molecular structure of the variable region of an IMMUNOGLOBULIN molecule that confers its antigenic specificity.
References in periodicals archive ?
2003) Idiotype - antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
In this case, the immune system will produce anti-idiotype antibodies to attack the idiotypes.
This test involves separation of EPO idiotypes by isoelectric focussing, immunoblotting, and detection of IgG labeled with streptiverdin-peroxidase.
By knowing the landscape of the AMMI parameter space, with the locations of current winners and the regions for potential and even universal new winners, desirable idiotypes can be defined.
Idiotypes can provoke anti-idiotypes, which in turn can provoke anti-idiotypes that attach to the initial provoker as well as to the anti-idiotype.
OMT together with US Pfizer (NYSE:PFE) have shown that the platform has a complete immune system with broad antibody repertoire, which generates antibodies with human idiotypes as robustly as a wild-type animals make rat antibodies.