Idiotope | definition of idiotope by Medical dictionary
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[idio- + -tope]
an antigenic determinant on a variable region of an immunoglobulin molecule.
A single antigenic determinant on a variable region of an antibody or T-cell receptor. A set of idiotopes make up the idiotype.
an antigenic determinant on the variable region of an antibody.
References in periodicals archive
The presence of a crossreactive idiotope on the heavy chains of many monoclonal antibodies against 3-FL suggested that their variable region structures might be very similar.
The levels of anti-3-FL antibodies and the crossreactive idiotope were comparable to those in conventional animals.
It is of course possible that a specific HAAA can also be directed against a particularly immunogenic specific idiotope found only in the peculiar antibody used for therapeutic purposes and not in related immunoglobulins.
In a practical sense, it is not be possible to distinguish an idiotope from a paratope because the binding sites are equivalent.
Although allotypic epitopes can be expressed by many IgG molecules independent of their isotype, idiotopes
that are formed by the variable region on the Fab portion mostly are unique epitopes.