ITGB7

ITGB7

A gene on chromosome 12q13.13 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-7 chain partners with the alpha-4 chain—Peyer patches-specific homing receptor LPAM-1—and serves as an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue. The A4/B7 heterodimer interacts with the cell surface adhesion molecules MADCAM1, VCAM1 and fibronectin.

Molecular pathology
A4B7 binds to HIV-1’s gp120 at the tripeptide LDI, facilitating HIV-1 entry to gut-associated lymphoid tissue, which is regarded as a major trigger of AIDS disease.
References in periodicals archive ?
This further activates integrins, including but not limit to, integrin [alpha]-4 (ITGA4) and ITGB7 (Additional File 17A) [13-15].
RT-PCR shows that SELE, SELL, ITGA4, ITGB7, and IL-10 are upregulated only at certain time points, but our RNA-seq data reveal that all genes tested are continuously upregulated following injury (Additional Files 5, 7, 9, and 11), indicating RNA-seq is more sensitive to show the statistical difference.
Molecules verified Pathways Function SELP, SELE, Agranulocyte/granulocyte Extravasation of SELPLG, SELL, adhesion and diapedesis agranulocyte-granulocyte, ITGA4 including (1) tethering, (2) Agranulocyte adhesion rolling and activation, (3) ITGB7 and diapedesis firm adhesion to the endothelium, (4) diapedesis, and (5) transen-dothelial migration JAK2 IL-6 Proinflammatory response IL-10 IL-10 Anti-inflammatory response