ITGB6

ITGB6

A gene on chromosome 2q24.2 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-6 chain partners with the alpha-5 chain to form a receptor for fibronectin and cytotactin, which recognises the RGD sequence in the ligands.
 
Molecular pathology
Clathrin-mediated endocytosis of integrin alpha-5/beta-6 promotes carcinoma invasion.
References in periodicals archive ?
Gbolahan et al., "Amplification of TGF[beta] induced ITGB6 gene transcription may promote pulmonary fibrosis," PLoS One, vol.
Areas of alveolar destruction because of neutrophil influx, foamy macrophages, and Clara cell hypertrophy Klotho Klotho is an "antiageing" hormone [62] Integrin beta-6 and transmembrane protein [63] (Itgb6) Inhibition of TGF-[beta] signaling causes increased expression of MMP- 12 by macrophages.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.3034.
Whereas the genes integrin a8 (ITGA8), ITGA4, and ITGA11 were up-regulated in NC cells only, ITGB6 was up-regulated in NEP cells only (relative to hESC).