ITGB6A gene on chromosome 2q24.2 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-6 chain partners with the alpha-5 chain to form a receptor for fibronectin and cytotactin, which recognises the RGD sequence in the ligands.
Clathrin-mediated endocytosis of integrin alpha-5/beta-6 promotes carcinoma invasion.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.