ITGB5

ITGB5

A gene on chromosome 3q21.2 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed one of 18 different alpha and one of 8 different beta chains). The beta-5 chain partners with the alpha-5 chain to form a fibronectin receptor that recognises the RGD sequence in the ligand.
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The phospholipase C beta 1 (PLCB1), PLCB4, adenylate cyclase 2 (ADCY2), ADCY8, calcium/calmodulin dependent protein kinase II beta (CAMK2B), CAMK2D, mitogen-activated protein kinase 11 (MAPK11), MAPK14, epidermal growth factor receptor (EGFR), growth factor receptor bound protein 2 (GRB2), Fyn proto-oncogene, Src family tyrosine kinase (FYN), and integrin subunit beta 5 (ITGB5) genes were involved in 12 significantly enriched pathways and accounted for 0.126% of the genetic variance for MY, 0.109% for FY, and 0.197% for AFC (Supplementary File SI).
From genes that are downregulated in female and upregulated in male sfx mice, we found 13 genes (Akt2, Sdc4, Myf6, Pabpn1, Itgb5, Tnnt2, MAP1, Pfn1, Tsix, Xist, Srebf1, Arf5, and Hdgf) that are connected to collagen synthesis.
Probe set ID Gene symbol Control G418 ATSE 7983763 MAPK6 233 314 382 8046380 ITGA6 216 323 385 8051670 SOS1 291 386 520 8084963 PAK2 173 252 360 8090162 ITGB5 330 357 220 8111915 SEPP1 3337 2847 1761 Probe set ID 1/2(G418 + ATSE) ATSE/control 7983763 405 1.64 8046380 220 1.78 8051670 515 1.79 8084963 338 2.08 8090162 150 -1.50 8111915 1131 -1.87 G418 (0.45 mg/mL); ATSE: Akebia trifoliate seed extract (0.625 mg/mL); 1/2(G418 + ATSE): a combination of half dose of each accordingly.