Genetic analysis has shown autosomal recessive pathogenic variants in the ITGA2B or ITGB3
, Astrocyte Elevated Gene-1 (AEG-1) , metadherin (MTDH) , and RUNX3 , they are all connected with EMT that regulates cell invasion and migration through targeted miR30a.
GT is a genetic autosomal recessive disease caused by the alteration of the genes ITGA2B and ITGB3
, located on the chromosome 17.
Chen et al., "MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3
and MAP4K3," Cancer Letters, vol.
(34,35) Both Integrin [alpha]v (Itgav) and Integrin [beta]3 (Itgb3
) subunits exhibited statistically significant modulation in this study, with the [alpha]v subunit showing more than 10-fold reduction in signal intensity over the early time interval in the necrotic zone.
With regard to ITGB3
, it was found that its mRNA expression remains constant in noncoated, BSA-coated, and Npnt-coated groups and was inhibited by both Fn and FCOL1.
Xu et al., "Association of platelet ITGA2B and ITGB3
polymorphisms with ex vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects," International Journal of Hematology, vol.
Of particular interest, the integrin cell adhesion receptor, beta-3 integrin (ITGB3
) was upregulated in regionally metastatic melanoma.
, beta-catenin and PECAM1), tubule formation factors (e.g.
In addition to these thrombophilias, important risk factors for perinatal and neonatal stroke include the p.L33P mutation in the b3 integrin gene (ITGB3
)  and the c.20210G > A polymorphism in the coagulation factor II gene (FII) [26-28].
The mRNAs included control housekeeping genes [actin, beta (ACTB)  and beta-2-microglobulin (B2M)] and myeloid [defensin, alpha 3, neutrophil-specific (DEFA3) and serglycin (SRGN)], erythroid [hemoglobin, beta (HBB) and uroporphyrinogen decarboxylase (UROD)], and megakaryocyte [integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) and integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ITGB3
)] lineage-specific genes.
proved that haslet-7c* inhibited migration and invasion of non-small cell lung cancer by targeting ITGB3
and MAP4K3 .