ITGB1

ITGB1

A gene on chromosome 10p11.2 that encodes an integrin beta chain protein, which forms part of receptors (with different alpha chains) for collagen, fibronectin, fibrinogen, laminin, VCAM1, cytotactin, osteopontin, vitronectin, epiligrin, thrombospondin and CSPG4. It is involved in embryogenesis, haemostasis, tissue repair, immune response and metastatic spread of malignant cells.
References in periodicals archive ?
The lncRNA HULC functions as an oncogene by targeting ATG7 and ITGB1 in epithelial ovarian carcinoma.
CD29, Integrin beta-1, is a protein encoded by ITGB1 gene in humans (Goodfellow et al., 1989).
In our previous study, we found that miR-29c inhibits the growth, invasion, and migration of PC cells by targeting integrin subunit beta 1 (ITGB1) [13].
This important member of the [beta]1 integrin family is composed of two chains: CD49d (alpha 4) encoded by ITGA4 gene and CD29 (beta 1) encoded by ITGB1. VLA-4 is mainly expressed on T cells, and it mediates the transmigration of T cells into the tissue by binding to its ligand VCAM-1 on endothelial cells.
Highly osteogenic PDL stem cell clones specifically express elevated levels of ICAM1, ITGB1 and TERT.
Such miR-29a-3p targeting might increase the expression of DNMT3B, VEGFA, and ITGB1 oncogenes, which suggested a possible involvement of H19 and circMYLK in the development, growth, and metastasis of bladder cancer [109].
Li et al., "hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation, " Gut, vol.
Of these, the integrin-collagen complex is a pharmacologically tractable target; various integrin signaling inhibitors include ITGA5 inhibitors (JSM 6427, PF-04605412, Volociximab, and Vitaxin), ITGB1 inhibitors (Volociximab, JSM 6427, R411, Vitaxin, and PF-04605412), and an ITGAV inhibitor (L000845704) (Figure 2(e)).
For the qRT-PCR of human COL4A3, ITGA6, and ITGB1, one microgram of total RNA was reverse transcribed into cDNA (ImProm 11 Reverse Transcription System, A3800, Promega, Madison, WI) with Oligo(dT) 15 Primer following manufacturer's instructions.
MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1. FEBS Lett.
Using 50kb flanking regions in the analysis of EAs, the top-ranked (#1) risk pathway was the 'cell-extracellular matrix interactions' pathway (RSU1, LIMS1, LIMS2, ARHGEF6, FERMT2, ACTN1, BLIM1, FLNC, ITGB1, PXN, FLNA, VASP, ILK, TESK1, PARVB, and PARVA) (p < 2.0E-4).
The lens expresses the laminin receptors [alpha]6[beta]1, [alpha]6[beta]4, and integrin and mice lacking either both the itga3 and itga6 or itgb1 genes from the lens develop profound lens abnormalities including loss of the lens epithelium and fiber cell defects [5, 65-67].