ITGA8

ITGA8

A gene on chromosome 10p13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in cell adhesion and cell surface-mediated signalling. Alpha 8 binds to a beta-1 chain, and is involved in the development of the kidneys and probably of other organs by regulating recruitment of mesenchymal cells into epithelial structures. It recognises the tripeptide sequence R-G-D in various ligands—e.g., TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. As a neuronal receptor for TNC, ITGA8 mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurones.
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These genes encoded proteins primarily involved in integrin signalling pathways (ACTA2, PIK3C2G, COL4A6, CAV1, LAMA1, FN1, and ITGA8), regulation of hormone levels (NR5A1, TIPARP, ACE, CRYM, CGA, ALDH1A1, TBX3, POMC, GHRH, and ALDH6), camera-type eye development (TGFBR2, BMP4, FABP7, STRA6, SIX6, and WNT6), blood vessel development (Figure S1, goo.gl/tC9GTZ), and regulation of cellular response to growth factor stimulus (see Figure 2).
Whereas the genes integrin a8 (ITGA8), ITGA4, and ITGA11 were up-regulated in NC cells only, ITGB6 was up-regulated in NEP cells only (relative to hESC).
Interestingly, expression of ITGA8, the reported potent receptor for Npnt, was found to be unaltered in Npnt-coated well.
In contrast, there was no elevation in the expression of ITGA8 as measured by quantitative RT-PCR in the Npnt-coated group.