ITGA8A gene on chromosome 10p13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in cell adhesion and cell surface-mediated signalling. Alpha 8 binds to a beta-1 chain, and is involved in the development of the kidneys and probably of other organs by regulating recruitment of mesenchymal cells into epithelial structures. It recognises the tripeptide sequence R-G-D in various ligands—e.g., TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. As a neuronal receptor for TNC, ITGA8 mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurones.
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