ITGA7

ITGA7

A gene on chromosome 12q13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 7 binds to a beta-1 chain, forming a receptor for laminin-1, a basement membrane protein, which is primarily expressed in skeletal and cardiac muscles. It appears to be involved in differentiation and migration processes during myogenesis.

Molecular pathology
ITGA7 mutations are associated with congenital myopathy.
References in periodicals archive ?
19] The a7 subunit is encoded by ITGA7 gene, expressed mainly in skeletal and cardiac muscle.
So far, this subtype has only described in three patients with normal laminin a2 but absent integrin a7 caused by mutations in ITGA7 gene.
Genetic screening of genes causing hereditary skeletal and cardiomyopathies was performed using targeted next-generation sequencing, and the screened gene panel included SGCD , TCAP , TRIM32 , TTN , FKTN , MYOT , LMNA , CAV3 , EMD , FHL1 , LAMA2 , ITGA7 , SEPN1 , ACTA1 , DES , CRYAB , LDB3 , BAG3 , STA , DMD , MYH7 , and LAMP2 .