ITGA5

ITGA5

A gene on chromosome 12q11-q13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 5 undergoes post-translational cleavage in its extracellular domain, yielding disulfide-linked light and heavy chains that bind to a beta-1 chain, forming a fibronectin and fibrinogen receptor, which also participates in adhesion and cell surface-mediated signalling.

Molecular pathology
The alpha-5 beta-1 heterodimer interacts with extracellular HIV-1 Tat protein, and is thought to enhance angiogenesis in Kaposi's sarcoma.
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Of these, the integrin-collagen complex is a pharmacologically tractable target; various integrin signaling inhibitors include ITGA5 inhibitors (JSM 6427, PF-04605412, Volociximab, and Vitaxin), ITGB1 inhibitors (Volociximab, JSM 6427, R411, Vitaxin, and PF-04605412), and an ITGAV inhibitor (L000845704) (Figure 2(e)).
For example, ethanol induced expression of the gene encoding fibronectin receptor subunit integrin alpha 5 (ITGA5).
Using the same method, seven highly ranked genes (BAP1, GRB14, HSP90AB1, ITGA5, NCKAP5L, SP1, and TOMM5) within [+ or -] 1 Mb of obesity SNPs were identified (Table 2).
Further analysis of the correlation pathways of genes disclosed that PRKCB, SP1, GRB14, LYN, and ITGA5 are correlated with each other (Figure 3).
When the scientists looked for the human version of the newly identified fly marker for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune genes they screened at the start of the study.
Testing ITGA5 activity in the saliva samples revealed that its activity levels increased during sleep deprivation.
There was no change in the expression of ITGA5 in the Npnt-coated group, while in the Fn-coated group, its expression was moderately attenuated as compared to control.
Except for the elevation of ITGA3 and ITGA7, FCOL1 downregulates the rest alpha integrins (ITGA1, ITGA2, ITGA4, and ITGA8) without impacting ITGA5 and ITGA6.
In cardiac ischemic condition, miR-92a targets integrin subunits a5 (ITGA5) and causes blockage on angiogenesis, which worsens the ischemic injury [188, 189].
6 identified proteins are involved in the PI3K-Akt signaling pathway, which are YWHAQ (14-3-3), YWHAH (14-3-3), ITGA5 (ITGA), ITGB1 (ITGB), PPP2R2A (PP2A), and PPP2R1A (PP2A) (Figure 5).
12 proteins were identified, associated with this cell process, which were SEC22B (Sec22), TUBB (TUBB), ITGA5 ([alpha]5[beta]1), ACTB (F-actin), ITGB2 (CR3), ITGB1 ([beta]1), TUBA1B (TUBA), ATB6V1B2 (vATPase), SEC22B (Sec22), CANX (calnexin), RAB5A (Rab5), and FCAR (FcaR) (Figure 6).
Another study reported that miR-92a was identified as a negative regulator of angiogenesis by targeting the A5 integrin subunit (ITGA5) [67].