IRF9

(redirected from ISGF3)
Also found in: Acronyms.

IRF9

A gene on chromosome 14q11.2 that encodes a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
Mentioned in ?
References in periodicals archive ?
As mentioned above, the RIP2-TRAF3-TBK1-IKK[epsilon]-IRF7 axis leading to signaling via the type I IFN receptor and activation of ISGF3 plays a major role in NOD1 induction of type I IFN responses in gastric epithelial cells.
pylori infection NOD1 is essential in the induction of protective type I IFN responses and activation of the ISGF3 signaling pathway.
2010) NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.