STAT1

(redirected from ISGF-3)

STAT1

A gene on chromosome 2q32.2 that encodes a member of the STAT family of transcription factors, which are phosphorylated by receptor-associated kinases in response to cytokines and growth factors. The STAT1 protein product is activated by IFN-alpha, IFN-gamma, EGF, PDGF and IL6; it mediates the expression of various genes, which is important for cell viability in response to different cell stimuli and pathogens.
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References in periodicals archive ?
STAT proteins are the key mediators of cytokine-induced gene expression and exert active role in anti-viral, anti-mycobacterial and anti-tumour responses against hepatitis.9 A recent review described multiple mechanisms related to JAK-STAT signalling pathway for modulation of HCV infection.10 Activated STAT-1 and STAT-2 bind IFN-regulatory factor 9 and form a heterotrimeric complex call ed IFN-stimulated gene factor3 (ISGF-3).
Thus, E7 inhibits IFN-[alpha] mediated signal transduction by a binding to P48/IRF-9 preventing translocation to the nucleus, thereby inhibiting the formation of the ISGF-3 transcription complex that binds ISRE (interferon specific response element) in the nucleus (60).