ISG15

A gene on chromosome 1p36.33 that encodes a ubiquitin-like protein which binds to target proteins in response to IFN-alpha or IFN-beta stimulation. ISG15 has chemotactic activity on neutrophils and activates them, triggering their release of eosinophil chemotactic factors. It may: play a role as a trans-acting binding factor, directing ligated target proteins to bind to intermediate filaments; have autocrine, paracrine and endocrine effects, including cell-to-cell signalling, possibly by inducing IFN-gamma secretion by macrophages; respond to IFN-tau secreted by the foetus; and bind and regulate proteins involved in the release of prostaglandin F2-alpha, preventing lysis of the corpus luteum and maintaining the pregnancy.

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USP18

References in periodicals archive ?

Mendelian Susceptibility to Mycobacterial Diseases MSMD has especially been associated with defects in the IL12B, IL12RB1, IRF8, ISG15, NEMO, IFNGR1, IFNGR2, STAT1, IRF8, and CYBB genes (15-22).

Frequency of Mycobacterium bovis and mycobacteria in primary immunodeficiencies

Cloning and sequence analysis of wild argali ISG15 cDNA.

Cloning and sequence analysis of Wild Argali short palate, lung and nasal epithelium clone 1 cDNA

Genetic disorders associated with inborn errors in IFN-[gamma]-dependent immunity include those which impair production of IFN-[gamma] (IL12B, IL12RB1, IRF8, ISG15, NEMO) and those which impair response to IFN-[gamma] (IFNGR1, IFNGR2, STAT1, IRF8, CYBB) [2].

Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis--a screen of osteoarticular lesions

Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases.

Genetic characterization of archived bunyaviruses and their potential for emergence in Australia

IFNa es producido en la mayoria de las celulas e induce Mx, ISG15 y actividad antiviral contra IPNV.

Progress and limitations of dsRNA strategies in the control of viral diseases in aquaculture/Avances y limitaciones en el uso de los dsRNA como estrategias de control y prevencion de enfermedades virales en sistemas acuicolas

Contudo, a infusao continua de roIFN-[TAU] na veia uterina resultou em maior expressao de ISG15 luteal quando comparada a injecao unica na arteria ovariana (10) e induziu nos animais tratados o prolongamento do intervalo entre estros e a manutencao de elevadas concentrares sericas de progesterona por ate para 32 dias.

Papel del interferon tau en el reconocimiento materno de la gestacion

Mesecar and his team captured the molecular structure of a key SARS enzyme, papain-like protease, and revealed how it strips a host cell of the proteins ubiquitin and ISG15, which are involved in triggering an immune response.

Vaccines for SARS, MERS viruses closer to reality

TANK (also known as I-TRAF) is a negative regulator of TLR-mediated proinflammatory cytokines, such as IL6 and TNF[alpha], but not ISGs, such as ISG15, through the suppression of TRAF6.

The membrane associated RING-CH proteins: a family of E3 ligases with diverse roles through the cell

The level of hepatitis B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 (USP18) expression.

Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns

A ISG15 (gene estimulado por inteferon 15) e uma proteina que possui funcao semelhante a uma ubiquitina (AUSTIN et al.

The role of interferon-tau during maternal recognition of pregnancy in ruminants/ Funcao do interferon-tau durante o reconhecimento materno da gestacao em ruminantes

OTCBB: ADXS), a leader in developing the next generation of immunotherapies for cancer and infectious diseases, has exclusively licensed the use of antigen ISG15 in Advaxis' Lm-LLO based immunotherapies from the University of Pennsylvania.

Advaxis Licenses Novel Antigen for Severe Breast Cancer and Other Tumor Types

ISG15 is induced as a disease resistance gene and expressed efficiently in mammalian cells after stimuli with IFNs and viruses (Der et al.