IRS2

IRS2

A gene on chromosome 13q34 that encodes a cytoplasmic signalling protein phosphorylated by insulin receptor tyrosine kinase; it mediates the effects of insulin, insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between various receptor tyrosine kinases and downstream effectors.
Mentioned in ?
References in periodicals archive ?
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55(10):2565-2582, PMID: 22869320, https://doi.org/10.1007/s00125012-2644-8.
There are two main IRS proteins present in our human bodies, and they are IRS1 and IRS2. Dr.
In addition, IRS1 and IRS2 promote Wnt/[beta]-catenin signaling that is critical for cell growth: it has been demonstrated that the dysregulation of this signaling pathway leads to cancer, obesity, and diabetes [60].
Fernandez et al., "Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling," Addiction Biology, vol.
Carbohydrate regulators affected were insulin receptor substrate 2 (Irs2), glucose-responsive fork head box O1 (Foxo1), and glucose trans- porter 2 (Slc2a2).
White, "Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2," Diabetologia, vol.
Furthermore, investigation showed that amplifications and mutations in the tyrosine kinase receptor adaptor gene (IRS2) may contribute to the increased sensitivity to anti-EGFR therapy, representing a potential biomarker to predict full response to anti-EGFR-related CRC therapy.
The deletion of both IRS1 and insulin receptor substrate 2 (IRS2) (H-DKO mice: heart-specific IRS1 and IRS2 double gene knock-out) in the brain and liver causes hyperglycemia, but such deficiencies in the pancreas and heart cause organ failure [98].
Other miR-30 mediated targets directly related to cell proliferation are Eya2, HP1y (CBX3), EZH2, IGF1R, RPA1, Notch, and IRS2. The Eya proteins (Eya1-4) are the eyes absent gene product in Drosophila.
Se ha observado que la adipoR1 mejora la sensibilidad a la insulina mediante AMPK al promover activacion del sustrato del receptor de la insulina 2 (Irs2) y PPAR[alfa] por ayudar con la oxidacion de acidos grasos (88).
[47] found that cinnamon extract supplementation resulted in reduced expression of interleukin-1[beta] (IL-1[beta]), IL-6, and tumor necrosis factor-[alpha] (TNF-[alpha]) mRNA while increasing expression of IR, IRS1, and IRS2 in hamster enterocytes.
Specific primer pairs (cross-intron) were designed based on the mRNA sequences of Rattus norvegicus (provided by NCBI) for insulin, glucagon (Gcg), glucokinase (Gck), glucose transporter type 2 (GLUT2), insulin receptor substrate 1 (Irs1), and insulin receptor substrate 2 (Irs2) and synthesized by TaKaRa (Table 2).