IRS1


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IRS1

A gene on chromosome 2q36 that encodes a protein phosphorylated by insulin receptor tyrosine kinase; it is thought to mediate the effects of insulin, insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between various receptor tyrosine kinases and downstream effectors.
 
Molecular pathology
IRS1 mutations are associated with type-2 diabetes and insulin resistance.
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References in periodicals archive ?
Zhu et al., "Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38a MAPK during insulin resistance," Diabetes, vol.
Andreozzi et al., "The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects," Atherosclerosis, vol.
Zou et al., "miR-195 inhibits tumor growth and angiogenesis through modulating IRS1 in breast cancer," Biomedicine & Pharmacotherapy, vol.
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
5A), and marein rescued the increased IRS1 protein levels caused by treatment with high glucose concentrations (Fig.
Considerando las anteriores premisas y la diversidad de la poblacion mexicana, se requiere hacer mas estudios de replica de genes asociados, como el realizado en diabeticos de las ciudades de Guerrero y Mexico en el que solo se encontro asociacion para variantes en IRS1 y TCF7L2 (39).
Using comparative transcriptomics in two model plant species I have identified a small family of genes (IRS1, IRS2 and BTS) that are good candidates for the plant Fe sensors.
The immunoblot results in the present study suggested that silibinin improved insulin resistance in C2C12 myotubes by preventing the inhibition of the insulin signaling pathway, including Tyr632 tyrosine phosphorylation of IRS1, PI3K activation, and Ser473 phosphorylation of Akt.
[2] found 'participation of Gly972Arg polymorphism of IRS1 in the genetic susceptibility to TD2 in Mexican population'.
The overall intra-assay percent coefficients of variation were 7.62%, 6.30%, 6.54%, and 4.59% for IRS1, Akt, 4EBP-1, and p70S6K, respectively.
It develops due to defects in insulin signaling including decreased insulin receptor tyrosine kinase activity defects in IRS1 (insulin recep-tor substrate1) and PI3 kinase (phosphatidyl3 kinase) activities that lead to a profound defect in glucose tran-sport and glycogen synthesis.2 Since insulin resistance is a key feature of type 2 diabetes mellitus therefore drug development has foc-ussed on developing drugs that increase insulin sensi-tivity otherwise known as insulin sensitizers.
En ese sentido, en el GWAS (genoma wide association study) se identifico un locus cerca IRS1 que esta asociado significativamente con el porcentaje de grasa corporal y que el incremento de este alelo presenta una fuerte asociacion con un perfil metabolico favorable (27).