Zhu et al., "Myocardial loss of IRS1
and IRS2 causes heart failure and is controlled by p38a MAPK during insulin resistance," Diabetes, vol.
Andreozzi et al., "The type 2 diabetes and insulin-resistance locus near IRS1
is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects," Atherosclerosis, vol.
Zou et al., "miR-195 inhibits tumor growth and angiogenesis through modulating IRS1
in breast cancer," Biomedicine & Pharmacotherapy, vol.
Association of Gly972Arg polymorphism of IRS1
gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
5A), and marein rescued the increased IRS1
protein levels caused by treatment with high glucose concentrations (Fig.
Considerando las anteriores premisas y la diversidad de la poblacion mexicana, se requiere hacer mas estudios de replica de genes asociados, como el realizado en diabeticos de las ciudades de Guerrero y Mexico en el que solo se encontro asociacion para variantes en IRS1
y TCF7L2 (39).
The immunoblot results in the present study suggested that silibinin improved insulin resistance in C2C12 myotubes by preventing the inhibition of the insulin signaling pathway, including Tyr632 tyrosine phosphorylation of IRS1
, PI3K activation, and Ser473 phosphorylation of Akt.
 found 'participation of Gly972Arg polymorphism of IRS1
in the genetic susceptibility to TD2 in Mexican population'.
The overall intra-assay percent coefficients of variation were 7.62%, 6.30%, 6.54%, and 4.59% for IRS1
, Akt, 4EBP-1, and p70S6K, respectively.
It develops due to defects in insulin signaling including decreased insulin receptor tyrosine kinase activity defects in IRS1
(insulin recep-tor substrate1) and PI3 kinase (phosphatidyl3 kinase) activities that lead to a profound defect in glucose tran-sport and glycogen synthesis.2 Since insulin resistance is a key feature of type 2 diabetes mellitus therefore drug development has foc-ussed on developing drugs that increase insulin sensi-tivity otherwise known as insulin sensitizers.