IRGM. Immunity-related GTPase family M protein (IRGM) has been considered to be associated to autophagy since 2006, though its specific molecular association with autophagy remains unclear .
Deretic, "Mechanism of action of the tuberculosis and Crohn disease risk factor IRGM in autophagy," Autophagy, vol.
Deretic, "Human IRGM induces autophagy to eliminate intracellular mycobacteria," Science, vol.
Kuballa et al., "Deletion polymorphism upstream of IRGM
associated with altered IRGM
expression and Crohn's disease," Nature Genetics, vol.
Gene Putative changes in IBD NOD2/CARD15 Impairment of pathogen recognition and [alpha]-defensin secretion NLRP3 Deregulation of IL-1[beta] synthesis ATG16L1 Impairment of autophagosome formation IRGM
Impairment of the process of autophagy PTPN2 Impairment of the process of autophagy in IEC FUT2 Impairment of the secretion of ABO antigens and alterations in gut microbiota JAK-2/STAT3 Alteration in T cell activation?
This IRGM version can't be properly regulated by small RNA molecules known as microRNAs, which help control how much of the protein gets made.
With this version of IRGM, there is an overabundance of the protein and an increase in formation of autophagosomes.
Medical interest in this gene ignited recently, when scientists associated specific IRGM mutations with the risk of Crohn's disease, an inflammatory digestive disorder.
In this latest study, the researchers reconstructed the evolutionary history of the IRGM locus within primates.
"The IRGM gene was dead and later resurrected through a complex series of structural events," Eichler said.
revealed that IRGM interacts with Atg5, Atg10, LC3, and SH3GBL1 and participates in the induction of autophagy and release of viral particles [149, 170].
Faure, "Autophagy and RNA virus interactomes reveal IRGM as a common target," Autophagy, vol.