IRF8


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IRF8

A gene on chromosome 16q24.1 that encodes interferon consensus sequence-binding protein (IRF8), a member of the interferon regulatory transcription factor (IRF) family, which have diverse roles such as virus-mediated activation of interferons and modulation of cell growth, differentiation, apoptosis and immune system activity.
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In a healthy state, IL-10 and IRF8 have no known interaction but both work in different ways to protect against invaders, Liu, a cancer immunologist in the MCG Department of Biochemistry and Molecular Biology, said.
The company is using a clinical trial assay to identify AML and MDS patients with elevated levels of RARA and IRF8 mRNA for inclusion in a Phase 2 clinical trial assessing the safety and efficacy of SY-1425 in combination with azacitidine, a hypomethylating agent, and in combination with daratumumab, an anti-CD38 therapeutic antibody.
(2012) IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype.
In CH published non-HLA loci SNPs showed significant association with SLE (Supplementary Table 3), including ETS1 (rs1128334, PCH = 2.4 x [10.sup.-3]), IRF8 (rs2280381, [P.sub.CH] = 1.38 x [10.sup.-2]), TNFAIP3 (rs5029939, [P.sub.CH] = 1.62 x [10.sup.-2]), STAT4 (rs3821236, [P.sub.CH] = 1.86 x [10.sup.-2]), and RASGRP3 (rs13385731, [P.sub.CH] = 3.63 x [10.sup.-2]).
The repression of Id2 would result in functioning E2-2 protein, which can reprogram precursors for the pDC lineage fate by upregulating Spi-B, IRF-7, and IRF8. There must be mechanisms in place to restrict GM-CSF signals from inhibiting IRF-8 through STAT5 to allow for [CD8.sup.+] cDC development, as well as pDCs.
The biomarker test being used to screen patients for the clinical trial is a qPCR-based clinical assay measuring RARA and IRF8 mRNA expression with a turnaround time of less than three days on average.
Kim et al., "Associations of CD6, TNFRSF1A and IRF8 polymorphisms with risk of inflammatory demyelinating diseases," Neuropathology and Applied Neurobiology, vol.
Additionally, the synthesis of interferon regulatory factor 8 (IRF8), a transcription factor, might be promoted by RBP-J via selectively augmenting IRAK2-Mnk1-eif4E axis signaling of TLR4 [62].
miRNA Expression level Cellular process miR-181a Upregulated by morphine Promote astrocyte-preferential differentiation of NSPCs miR-23b Upregulated by morphine Adult neurogenesis miR-190 Downregulated by fentanyl Adult neurogenesis miR-143 Upregulation by IGF-1 Promotes proliferation, neural differentiation, and cell survival miR-181c Upregulation by IGF1/LIF Enhanced self-renewal of NSPCs miRNA Molecular target Reference miR-181a Prox1/Notch2 [159] miR-23b Morphine receptor expression (MOR1) [160] miR-190 NeuroD [161] miR-143 PDGFRA, PRKCE, MAPK7, DSSP, DMP-1, [162] KRAS, and BCL-2 miR-181c PTPN11, PTPN22, PTEN, Dusp6, PBX3, ZEB2, [162] and IRF8
They also showed that vitamin D had a significant effect on the activity of 229 genes including IRF8, previously associated with MS, and PTPN2, associated with Crohn's disease and type 1 diabetes.
Patent 9,868,994, covers a method of treating AML and MDS by administering SY-1425 to patients known to have elevated levels of IRF8 mRNA.
The first group of signals activated downstream transcription factors or pathways like STAT3, IRF8, C/EBP[beta], RB1, Notch, adenosine receptors A2b signaling, and NLRP3 for MDSC expansion [23].