After differential regulatory network construction and TED scoring, we found that the interferon regulatory factor ( IRF ) family members, including IRF1, IRF3, IRF5, IRF7
, and IRF9, are important TFs in the early stage of DN.
upregulates ATF4 activity and expression, whereas ATF4 in return inhibits IRF7
In the first set (Figure 7(b)) are genes related to the interferon response genes, including Irf1, Ifi44, Irf7
, and Oas1g.
This leads to the activation of IRF3/ IRF7
and NF-[kappa]B, which results in the production of type 1 IFNs and inflammatory cytokines, respectively [74, 78].
These 719 genes are enriched in immune response pathways, such as interferon signaling, as demonstrated by the interferon regulatory factor 7 (Irf7
) locus (Figure 4C; see also Excel Table S9).
(10) This pathway involves activation of TANK-binding kinase 1 (TBK1) and I[kappa]B kinase [epsilon] (IKK[epsilon]) followed by nuclear translocation of IRF7
, a transcription factor acting directly as a transcription factor for type I IFN promoter and indirectly through its induction of type I IFN and the latter's induction of ISGF3.
The baseline expression levels of 25 IFN-regulated genes (MxA, GPR3, IL17RC, ISG15, TRAIL, OASL, IFIT1, IFIT2, RSAD2, OAS3, IFI44L, TRIM22, IL10, CXCL10, STAT1, OAS1, OAS2, IFNAR1, IFNAR2, IFN[beta], ISG20, IFI6, PKR, IRF7
, and USP18) were examined but were not confirmed to have predictive value .
In H3N2 infection, some DNBs are involved in defense response (e.g., SIGLEC1, TNFAIP6, IRF7
, SAMHD1, TLR7, DHX58, and CXCL10) and inflammatory response (e.g., SIGLEC1, TNFAiP6, IRF7
, TLR7, and CXCL10).
Host genetics of severe influenza: from mouse Mx1 to human IRF7
. Current Opinion in Immunology, 38, 109-120.
MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7
in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes.
Nuestros resultados soportan esta informacion, ya que observamos que muchos genes inducibles y regulados por IFN[gamma], tales como IFI-16, IFI-30, IFI-44, IRF-3, IRF7
y IRF-1 estuvieron aumentados en los granulomas.
[Source:RefSeq mRNA;Acc:NM_001099937] ENSSSCG00000005717 uridine-cytidine kinase 1 [Source:HGNC Symbol;Acc:14859] ENSSSCG00000029715 olfactomedin 1 [Source:HGNC Symbol;Acc:17187] ENSSSCG00000005841 RAB, member RAS oncogene family-like 6 [Source:HGNC Symbol;Acc:24703] ENSSSCG00000012834 mucin 5B, oligomeric mucus/gel-forming [Source:HGNC Symbol;Acc:7516] ENSSSCG00000012837 chitinase domain containing 1 [Source:HGNC Symbol;Acc:28474] ENSSSCG00000012853 Sus scrofa interferon regulatory factor 7 (IRF7